ROBINET, Pauline; MOLLET, Lucile; GONZALEZ, Patrick; NORMAND, Thierry; CHARPENTIER, Stephane; BRULE, Fabienne; DUBOIS, Martine; LEGRAND, Alain

doi:10.1016/j.bbrc.2009.12.162

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ROBINET, Pauline
Centre de biophysique moléculaire [CBM]

MOLLET, Lucile
Centre de biophysique moléculaire [CBM]

GONZALEZ, Patrick
Centre de biophysique moléculaire [CBM]

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Biochemical and Biophysical Research Communications. 2010, vol. 392, n° 1, p. 53-57

Elsevier

Résumé en anglais

Mitogaligin, a protein encoded by galig, an internal cytotoxic gene of the galectin-3 locus, is mostly a mitochondrial protein. Mitochondrial targeting is due to an already identified mitochondrial localization signal. Interaction of mitogaligin with mitochondria leads to cytochrome c cytosolic leakage and ultimately to cell death. We have previously pointed out that mitogaligin can also be directed to the nucleus when the mitochondrial addressing signal is inactivated, indicating a possible dual intracellular localization of the protein. When expressed in the nucleus, mitogaligin exhibits also apoptotic properties leading to cell death. In this report, we show that nuclear addressing of mitogaligin depends on a sequence differing from classical signals containing basic, lysine or proline-tyrosine rich residues. The signal consists of a long sequence of amino acids residues based on a series of a short repetitive degenerated sequence.< Réduire

Mots clés en italien

Unconventional nuclear localization signal

Mitogaligin

Dual localization

CELL-DEATH PROTEIN

INTRACELLULAR-LOCALIZATION

MOLECULAR-CLONING

IDENTIFICATION

SEQUENCE

IMPORTIN

VIRUS

GENE

TRANSLOCATION

MITOCHONDRIA

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The mitogaligin protein is addressed to the nucleus via a non-classical localization signal

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