YU, Qiang; GAMAYUN, Igor; WARTENBERG, Philipp; ZHANG, Qian; QIAO, Sen; KUSUMAKSHI, Soumya; CANDLISH, Sarah; GÖTZ, Viktoria; WEN, Shuping; DAS, Debajyoti; WYATT, Amanda; WAHL, Vanessa; ECTORS, Fabien; KATTLER, Kathrin; YILDIZ, Daniela; PREVOT, Vincent; SCHWANINGER, Markus; TERNIER, Gaetan; GIACOBINI, Paolo; CIOFI, Philippe; MULLER, Timo D.; BOEHM, Ulrich

doi:10.1038/s41467-023-37099-3

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Article de revue

Ce document a été publié dans

Nature Communications. 2023-03-22, vol. 14, n° 1

Résumé en anglais

The median eminence (ME) is a circumventricular organ at the base of the brain that controls body homeostasis. Tanycytes are its specialized glial cells that constitute the ventricular walls and regulate different physiological states, however individual signaling pathways in these cells are incompletely understood. Here, we identify a functional tanycyte subpopulation that expresses key taste transduction genes including bitter taste receptors, the G protein gustducin and the gustatory ion channel TRPM5 (M5). M5 tanycytes have access to blood-borne cues via processes extended towards diaphragmed endothelial fenestrations in the ME and mediate bidirectional communication between the cerebrospinal fluid and blood. This subpopulation responds to metabolic signals including leptin and other hormonal cues and is transcriptionally reprogrammed upon fasting. Acute M5 tanycyte activation induces insulin secretion and acute diphtheria toxin-mediated M5 tanycyte depletion results in impaired glucose tolerance in diet-induced obese mice. We provide a cellular and molecular framework that defines how bitter taste cells in the ME integrate chemosensation with metabolism. © 2023, The Author(s).< Réduire

Mots clés en anglais

Signal Transduction

Adult

Animal cell

Animal experiment

Animal tissue

Arcuate nucleus

Bitter taste

Blood analysis

Brain slice

Brain third ventricle

Brain ventricle

Brain ventricle wall

Cerebrospinal fluid

Chemosensing

Controlled study

Diaphragm

Diet-induced obesity

Energy metabolism

Female

Fenestration

Glucose homeostasis

Hypothalamus

Impaired glucose tolerance

Insulin release

Median eminence

Molecular biology

Mouse

Tanycyte

Taste bud cell

Homeostasis

Physiology

URI

https://oskar-bordeaux.fr/handle/20.500.12278/188965

DOI

http://dx.doi.org/10.1038/s41467-023-37099-3

Unités de recherche

Neurocentre Magendie - U1215

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Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis

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Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche