Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis
CIOFI, Philippe
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
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Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Idioma
EN
Article de revue
Este ítem está publicado en
Nature Communications. 2023-03-22, vol. 14, n° 1
Resumen en inglés
The median eminence (ME) is a circumventricular organ at the base of the brain that controls body homeostasis. Tanycytes are its specialized glial cells that constitute the ventricular walls and regulate different physiological ...Leer más >
The median eminence (ME) is a circumventricular organ at the base of the brain that controls body homeostasis. Tanycytes are its specialized glial cells that constitute the ventricular walls and regulate different physiological states, however individual signaling pathways in these cells are incompletely understood. Here, we identify a functional tanycyte subpopulation that expresses key taste transduction genes including bitter taste receptors, the G protein gustducin and the gustatory ion channel TRPM5 (M5). M5 tanycytes have access to blood-borne cues via processes extended towards diaphragmed endothelial fenestrations in the ME and mediate bidirectional communication between the cerebrospinal fluid and blood. This subpopulation responds to metabolic signals including leptin and other hormonal cues and is transcriptionally reprogrammed upon fasting. Acute M5 tanycyte activation induces insulin secretion and acute diphtheria toxin-mediated M5 tanycyte depletion results in impaired glucose tolerance in diet-induced obese mice. We provide a cellular and molecular framework that defines how bitter taste cells in the ME integrate chemosensation with metabolism. © 2023, The Author(s).< Leer menos
Palabras clave en inglés
Signal Transduction
Adult
Animal cell
Animal experiment
Animal tissue
Arcuate nucleus
Bitter taste
Blood analysis
Brain slice
Brain third ventricle
Brain ventricle
Brain ventricle wall
Cerebrospinal fluid
Chemosensing
Controlled study
Diaphragm
Diet-induced obesity
Energy metabolism
Female
Fenestration
Glucose homeostasis
Hypothalamus
Impaired glucose tolerance
Insulin release
Median eminence
Molecular biology
Mouse
Tanycyte
Taste bud cell
Homeostasis
Physiology
Centros de investigación