Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis
| dc.rights.license | open | en_US |
| dc.contributor.author | YU, Qiang | |
| dc.contributor.author | GAMAYUN, Igor | |
| dc.contributor.author | WARTENBERG, Philipp | |
| dc.contributor.author | ZHANG, Qian | |
| dc.contributor.author | QIAO, Sen | |
| dc.contributor.author | KUSUMAKSHI, Soumya | |
| dc.contributor.author | CANDLISH, Sarah | |
| dc.contributor.author | GÖTZ, Viktoria | |
| dc.contributor.author | WEN, Shuping | |
| dc.contributor.author | DAS, Debajyoti | |
| dc.contributor.author | WYATT, Amanda | |
| dc.contributor.author | WAHL, Vanessa | |
| dc.contributor.author | ECTORS, Fabien | |
| dc.contributor.author | KATTLER, Kathrin | |
| dc.contributor.author | YILDIZ, Daniela | |
| dc.contributor.author | PREVOT, Vincent | |
| dc.contributor.author | SCHWANINGER, Markus | |
| dc.contributor.author | TERNIER, Gaetan | |
| dc.contributor.author | GIACOBINI, Paolo | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CIOFI, Philippe | |
| dc.contributor.author | MULLER, Timo D. | |
| dc.contributor.author | BOEHM, Ulrich | |
| dc.date.accessioned | 2024-03-25T15:35:58Z | |
| dc.date.available | 2024-03-25T15:35:58Z | |
| dc.date.issued | 2023-03-22 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/188965 | |
| dc.description.abstractEn | The median eminence (ME) is a circumventricular organ at the base of the brain that controls body homeostasis. Tanycytes are its specialized glial cells that constitute the ventricular walls and regulate different physiological states, however individual signaling pathways in these cells are incompletely understood. Here, we identify a functional tanycyte subpopulation that expresses key taste transduction genes including bitter taste receptors, the G protein gustducin and the gustatory ion channel TRPM5 (M5). M5 tanycytes have access to blood-borne cues via processes extended towards diaphragmed endothelial fenestrations in the ME and mediate bidirectional communication between the cerebrospinal fluid and blood. This subpopulation responds to metabolic signals including leptin and other hormonal cues and is transcriptionally reprogrammed upon fasting. Acute M5 tanycyte activation induces insulin secretion and acute diphtheria toxin-mediated M5 tanycyte depletion results in impaired glucose tolerance in diet-induced obese mice. We provide a cellular and molecular framework that defines how bitter taste cells in the ME integrate chemosensation with metabolism. © 2023, The Author(s). | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Signal Transduction | |
| dc.subject.en | Adult | |
| dc.subject.en | Animal cell | |
| dc.subject.en | Animal experiment | |
| dc.subject.en | Animal tissue | |
| dc.subject.en | Arcuate nucleus | |
| dc.subject.en | Bitter taste | |
| dc.subject.en | Blood analysis | |
| dc.subject.en | Brain slice | |
| dc.subject.en | Brain third ventricle | |
| dc.subject.en | Brain ventricle | |
| dc.subject.en | Brain ventricle wall | |
| dc.subject.en | Cerebrospinal fluid | |
| dc.subject.en | Chemosensing | |
| dc.subject.en | Controlled study | |
| dc.subject.en | Diaphragm | |
| dc.subject.en | Diet-induced obesity | |
| dc.subject.en | Energy metabolism | |
| dc.subject.en | Female | |
| dc.subject.en | Fenestration | |
| dc.subject.en | Glucose homeostasis | |
| dc.subject.en | Hypothalamus | |
| dc.subject.en | Impaired glucose tolerance | |
| dc.subject.en | Insulin release | |
| dc.subject.en | Median eminence | |
| dc.subject.en | Molecular biology | |
| dc.subject.en | Mouse | |
| dc.subject.en | Tanycyte | |
| dc.subject.en | Taste bud cell | |
| dc.subject.en | Homeostasis | |
| dc.subject.en | Physiology | |
| dc.title.en | Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis | |
| dc.title.alternative | Nat Commun | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41467-023-37099-3 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 36949050 | en_US |
| bordeaux.journal | Nature Communications | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Relations glie-neurone | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | European Research Council | en_US |
| bordeaux.identifier.funderID | Deutsche Forschungsgemeinschaft | en_US |
| hal.identifier | hal-04520472 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-03-25T15:36:03Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2023-03-22&rft.volume=14&rft.issue=1&rft.au=YU,%20Qiang&GAMAYUN,%20Igor&WARTENBERG,%20Philipp&ZHANG,%20Qian&QIAO,%20Sen&rft.genre=article |
