TIN, Adrienne; FOHNER, Alison E; YANG, Qiong; BRODY, Jennifer A; DAVIES, Gail; YAO, Jie; LIU, Dan; CARO, Ilana; LINDBOHM, Joni V; DUGGAN, Michael R; MEIRELLES, Osorio; HARRIS, Sarah E; GUDMUNDSDOTTIR, Valborg; TAYLOR, Adele M; HENRY, Albert; BEISER, Alexa S; SHOJAIE, Ali; COORS, Annabell; FITZPATRICK, Annette L; LANGENBERG, Claudia; SATIZABAL, Claudia L; SITLANI, Colleen M; WHEELER, Eleanor; TUCKER-DROB, Elliot M; BRESSLER, Jan; CORESH, Josef; BIS, Joshua C; CANDIA, Julian; JENNINGS, Lori L; PIETZNER, Maik; LATHROP, Mark; LOPEZ, Oscar L; REDMOND, Paul; GERSZTEN, Robert E; RICH, Stephen S; HECKBERT, Susan R; AUSTIN, Thomas R; HUGHES, Timothy M; TANAKA, Toshiko; EMILSSON, Valur; VASAN, Ramachandran S; GUO, Xiuqing; ZHU, Yineng; TZOURIO, Christophe; ROTTER, Jerome I; WALKER, Keenan A; FERRUCCI, Luigi; KIVIMAKI, Mika; BRETELER, Monique M B; COX, Simon R; DEBETTE, Stephanie; MOSLEY, Thomas H; GUDNASON, Vilmundur G; LAUNER, Lenore J; PSATY, Bruce M; SESHADRI, Sudha; FORNAGE, Myriam

doi:10.1038/s42003-023-05454-1

Langue

Article de revue

Ce document a été publié dans

Communications Biology. 2023-11-03, vol. 6, n° 1, p. 1117

Résumé en anglais

Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p<4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer's disease (AD) risk (p=2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p<2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets. Analysis of circulating proteins across multiple cohorts identifies proteins that are associated with cognitive function and may serve as targets to understand the relationship between immunity and Alzheimer's disease risk.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/187327

DOI

http://dx.doi.org/10.1038/s42003-023-05454-1

Project ANR

Stopping cognitive decline and dementia by fighting covert cerebral small vessel disease

Voir/Ouvrir

Métadonnées

Licence d’utilisation du document

Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Project ANR

Unités de recherche

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Project ANR

Unités de recherche