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Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

dc.rights.licenseopenen_US
dc.contributor.authorTIN, Adrienne
dc.contributor.authorFOHNER, Alison E
dc.contributor.authorYANG, Qiong
dc.contributor.authorBRODY, Jennifer A
dc.contributor.authorDAVIES, Gail
dc.contributor.authorYAO, Jie
dc.contributor.authorLIU, Dan
dc.contributor.authorCARO, Ilana
dc.contributor.authorLINDBOHM, Joni V
dc.contributor.authorDUGGAN, Michael R
dc.contributor.authorMEIRELLES, Osorio
dc.contributor.authorHARRIS, Sarah E
dc.contributor.authorGUDMUNDSDOTTIR, Valborg
dc.contributor.authorTAYLOR, Adele M
dc.contributor.authorHENRY, Albert
dc.contributor.authorBEISER, Alexa S
dc.contributor.authorSHOJAIE, Ali
dc.contributor.authorCOORS, Annabell
dc.contributor.authorFITZPATRICK, Annette L
dc.contributor.authorLANGENBERG, Claudia
dc.contributor.authorSATIZABAL, Claudia L
dc.contributor.authorSITLANI, Colleen M
dc.contributor.authorWHEELER, Eleanor
dc.contributor.authorTUCKER-DROB, Elliot M
dc.contributor.authorBRESSLER, Jan
dc.contributor.authorCORESH, Josef
dc.contributor.authorBIS, Joshua C
dc.contributor.authorCANDIA, Julian
dc.contributor.authorJENNINGS, Lori L
dc.contributor.authorPIETZNER, Maik
dc.contributor.authorLATHROP, Mark
dc.contributor.authorLOPEZ, Oscar L
dc.contributor.authorREDMOND, Paul
dc.contributor.authorGERSZTEN, Robert E
dc.contributor.authorRICH, Stephen S
dc.contributor.authorHECKBERT, Susan R
dc.contributor.authorAUSTIN, Thomas R
dc.contributor.authorHUGHES, Timothy M
dc.contributor.authorTANAKA, Toshiko
dc.contributor.authorEMILSSON, Valur
dc.contributor.authorVASAN, Ramachandran S
dc.contributor.authorGUO, Xiuqing
dc.contributor.authorZHU, Yineng
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorROTTER, Jerome I
dc.contributor.authorWALKER, Keenan A
dc.contributor.authorFERRUCCI, Luigi
dc.contributor.authorKIVIMAKI, Mika
dc.contributor.authorBRETELER, Monique M B
dc.contributor.authorCOX, Simon R
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorMOSLEY, Thomas H
dc.contributor.authorGUDNASON, Vilmundur G
dc.contributor.authorLAUNER, Lenore J
dc.contributor.authorPSATY, Bruce M
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorFORNAGE, Myriam
dc.date.accessioned2024-01-18T08:42:05Z
dc.date.available2024-01-18T08:42:05Z
dc.date.issued2023-11-03
dc.identifier.issn2399-3642en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187327
dc.description.abstractEnIdentifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p<4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer's disease (AD) risk (p=2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p<2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets. Analysis of circulating proteins across multiple cohorts identifies proteins that are associated with cognitive function and may serve as targets to understand the relationship between immunity and Alzheimer's disease risk.
dc.description.sponsorshipStopping cognitive decline and dementia by fighting covert cerebral small vessel diseaseen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enIdentification of circulating proteins associated with general cognitive function among middle-aged and older adults
dc.title.alternativeCommun Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s42003-023-05454-1en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37923804en_US
bordeaux.journalCommunications Biologyen_US
bordeaux.page1117en_US
bordeaux.volume6en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDHorizon 2020en_US
hal.identifierhal-04402104
hal.version1
hal.date.transferred2024-01-18T08:42:10Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Communications%20Biology&amp;rft.date=2023-11-03&amp;rft.volume=6&amp;rft.issue=1&amp;rft.spage=1117&amp;rft.epage=1117&amp;rft.eissn=2399-3642&amp;rft.issn=2399-3642&amp;rft.au=TIN,%20Adrienne&amp;FOHNER,%20Alison%20E&amp;YANG,%20Qiong&amp;BRODY,%20Jennifer%20A&amp;DAVIES,%20Gail&amp;rft.genre=article


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