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High-Level Resistance to Colistin Mediated by Various Mutations in the Gene among Carbapenemase-Producing Klebsiella pneumoniae.
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Article de revue
Este ítem está publicado en
Antimicrobial Agents and Chemotherapy. 2017-11-01, vol. 61, n° 11
Resumen en inglés
Mutations in genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant isolates. Four isolates, respectively, producing carbapenemases ...Leer más >
Mutations in genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB protein restored the susceptibility to colistin in all cases, confirming the involvement of the identified substitutions in the resistance phenotype.< Leer menos
Palabras clave en inglés
Amino Acid Substitution
Anti-Bacterial Agents
Bacterial Proteins
Colistin
Drug Resistance
Bacterial
Gene Expression Regulation
Bacterial
Genetic Complementation Test
Humans
Klebsiella pneumoniae
Microbial Sensitivity Tests
Mutation
beta-Lactamases
Centros de investigación