High-Level Resistance to Colistin Mediated by Various Mutations in the Gene among Carbapenemase-Producing Klebsiella pneumoniae.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | JAYOL, Aurélie | |
| hal.structure.identifier | Université de Fribourg = University of Fribourg [UNIFR] | |
| dc.contributor.author | NORDMANN, Patrice | |
| hal.structure.identifier | University of Cape Town | |
| dc.contributor.author | BRINK, Adrian | |
| dc.contributor.author | VILLEGAS, Maria-Virginia | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | DUBOIS, Véronique | |
| hal.structure.identifier | Université de Fribourg = University of Fribourg [UNIFR] | |
| dc.contributor.author | POIREL, Laurent | |
| dc.date.accessioned | 2023-11-21T14:19:02Z | |
| dc.date.available | 2023-11-21T14:19:02Z | |
| dc.date.issued | 2017-11-01 | |
| dc.identifier.issn | 1098-6596 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/186018 | |
| dc.description.abstractEn | Mutations in genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin-resistant isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB protein restored the susceptibility to colistin in all cases, confirming the involvement of the identified substitutions in the resistance phenotype. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Amino Acid Substitution | |
| dc.subject.en | Anti-Bacterial Agents | |
| dc.subject.en | Bacterial Proteins | |
| dc.subject.en | Colistin | |
| dc.subject.en | Drug Resistance | |
| dc.subject.en | Bacterial | |
| dc.subject.en | Gene Expression Regulation | |
| dc.subject.en | Bacterial | |
| dc.subject.en | Genetic Complementation Test | |
| dc.subject.en | Humans | |
| dc.subject.en | Klebsiella pneumoniae | |
| dc.subject.en | Microbial Sensitivity Tests | |
| dc.subject.en | Mutation | |
| dc.subject.en | beta-Lactamases | |
| dc.title.en | High-Level Resistance to Colistin Mediated by Various Mutations in the Gene among Carbapenemase-Producing Klebsiella pneumoniae. | |
| dc.title.alternative | Antimicrob Agents Chemother | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1128/AAC.01423-17 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 28874377 | en_US |
| bordeaux.journal | Antimicrobial Agents and Chemotherapy | en_US |
| bordeaux.volume | 61 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 11 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04297980 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-11-21T14:19:04Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Antimicrobial%20Agents%20and%20Chemotherapy&rft.date=2017-11-01&rft.volume=61&rft.issue=11&rft.eissn=1098-6596&rft.issn=1098-6596&rft.au=JAYOL,%20Aur%C3%A9lie&NORDMANN,%20Patrice&BRINK,%20Adrian&VILLEGAS,%20Maria-Virginia&DUBOIS,%20V%C3%A9ronique&rft.genre=article |
