Scaling-up metabolomics: Current state and perspectives
BARROS SANTOS, Millena Cristina
Plateforme Bordeaux Metabolome
Biologie du fruit et pathologie [BFP]
Plateforme Bordeaux Metabolome
Biologie du fruit et pathologie [BFP]
BERTRAND-MICHEL, Justine
Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
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Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
BARROS SANTOS, Millena Cristina
Plateforme Bordeaux Metabolome
Biologie du fruit et pathologie [BFP]
Plateforme Bordeaux Metabolome
Biologie du fruit et pathologie [BFP]
BERTRAND-MICHEL, Justine
Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
CASTELLI, Florence
MetaboHUB-IDF
Médicaments et Technologies pour la Santé [MTS]
Service de Pharmacologie et Immunoanalyse [SPI]
CEA- Saclay [CEA]
Université Paris-Saclay
Laboratoire Innovations en Spectrométrie de Masse pour la santé [LI-MS]
Small molecule analysis and omics [SMART-OMICS]
MetaboHUB-IDF
Médicaments et Technologies pour la Santé [MTS]
Service de Pharmacologie et Immunoanalyse [SPI]
CEA- Saclay [CEA]
Université Paris-Saclay
Laboratoire Innovations en Spectrométrie de Masse pour la santé [LI-MS]
Small molecule analysis and omics [SMART-OMICS]
CREUSOT, Nicolas
Plateforme Bordeaux Metabolome
Ecosystèmes aquatiques et changements globaux [UR EABX]
Plateforme Bordeaux Metabolome
Ecosystèmes aquatiques et changements globaux [UR EABX]
GUITTON, Yann
Laboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA]
Plateforme Metabolomics, Lipidomics and Steroidomics Analysis [MELISA]
< Reduce
Laboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA]
Plateforme Metabolomics, Lipidomics and Steroidomics Analysis [MELISA]
Language
en
Article de revue
This item was published in
Trends in Analytical Chemistry. 2023, vol. 167, n° 20, p. 117225
Elsevier
English Abstract
Metabolomics is now a mature phenotyping tool that provides substantial results within various scientific communities. Its application at large-scale, i.e. on large populations and/or samples, has shown its power for ...Read more >
Metabolomics is now a mature phenotyping tool that provides substantial results within various scientific communities. Its application at large-scale, i.e. on large populations and/or samples, has shown its power for research activities from plant science to human epidemiology and medicine, but it still needs key methodological developments for its routine application. Here, we review the current state of large-scale metabolomics applications, providing recent examples of large cohort studies in human and plant/environment research, and present the remaining scientific challenges of both fields. Then, we address the key common methodological issues, from analytics to data science, to fulfil these objectives and go towards a more comprehensive and interoperable large-scale metabolomics, making it a new key actor in the frame of the One-Health future research.Read less <
English Keywords
Cohort
Data science
Interoperability
Large-scale
Mass spectrometry
Metabolomics
Nuclear magnetic resonance
One-health
European Project
summit
ANR Project
Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation - ANR-11-INBS-0010
Centre français de phénomique végétale - ANR-11-INBS-0012
Centre français de phénomique végétale - ANR-11-INBS-0012
Origin
Hal importedCollections