hal.structure.identifier | Plateforme Exploration du Métabolisme [PFEM] | |
dc.contributor.author | HAJJAR, Ghina | |
hal.structure.identifier | Plateforme Bordeaux Metabolome | |
hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
dc.contributor.author | BARROS SANTOS, Millena Cristina | |
hal.structure.identifier | Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC] | |
dc.contributor.author | BERTRAND-MICHEL, Justine | |
hal.structure.identifier | Metatoul AXIOM [E20] | |
dc.contributor.author | CANLET, Cécile | |
hal.structure.identifier | MetaboHUB-IDF | |
hal.structure.identifier | Médicaments et Technologies pour la Santé [MTS] | |
hal.structure.identifier | Service de Pharmacologie et Immunoanalyse [SPI] | |
hal.structure.identifier | CEA- Saclay [CEA] | |
hal.structure.identifier | Université Paris-Saclay | |
hal.structure.identifier | Laboratoire Innovations en Spectrométrie de Masse pour la santé [LI-MS] | |
hal.structure.identifier | Small molecule analysis and omics [SMART-OMICS] | |
dc.contributor.author | CASTELLI, Florence | |
hal.structure.identifier | Plateforme Bordeaux Metabolome | |
hal.structure.identifier | Ecosystèmes aquatiques et changements globaux [UR EABX] | |
dc.contributor.author | CREUSOT, Nicolas | |
hal.structure.identifier | MetaboHUB-IDF | |
hal.structure.identifier | Médicaments et Technologies pour la Santé [MTS] | |
dc.contributor.author | DECHAUMET, Sylvain | |
hal.structure.identifier | Plateforme Exploration du Métabolisme [PFEM] | |
dc.contributor.author | DIÉMÉ, Binta | |
hal.structure.identifier | Unité de Nutrition Humaine [UNH] | |
dc.contributor.author | GIACOMONI, Franck | |
hal.structure.identifier | Magnetic resonance, Isotopomics, Metabolomics, Monitoring [MIMM] | |
dc.contributor.author | GIRAUDEAU, Patrick | |
hal.structure.identifier | Laboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA] | |
hal.structure.identifier | Plateforme Metabolomics, Lipidomics and Steroidomics Analysis [MELISA] | |
dc.contributor.author | GUITTON, Yann | |
hal.structure.identifier | Médicaments et Technologies pour la Santé [MTS] | |
hal.structure.identifier | MetaboHUB-IDF | |
dc.contributor.author | THÉVENOT, Etienne A | |
hal.structure.identifier | Metatoul AXIOM [E20] | |
dc.contributor.author | TREMBLAY-FRANCO, Marie | |
hal.structure.identifier | MetaboHUB-IDF | |
hal.structure.identifier | Médicaments et Technologies pour la Santé [MTS] | |
dc.contributor.author | JUNOT, Christophe | |
hal.structure.identifier | Métabolisme et Xénobiotiques [ToxAlim-MeX] | |
dc.contributor.author | JOURDAN, Fabien | |
hal.structure.identifier | MetaboHUB-IDF | |
hal.structure.identifier | Médicaments et Technologies pour la Santé [MTS] | |
dc.contributor.author | FENAILLE, François | |
hal.structure.identifier | Plateforme Exploration du Métabolisme [PFEM] | |
dc.contributor.author | COMTE, Blandine | |
hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
hal.structure.identifier | Plateforme Bordeaux Metabolome | |
dc.contributor.author | PÉTRIACQ, Pierre | |
hal.structure.identifier | Plateforme Exploration du Métabolisme [PFEM] | |
dc.contributor.author | PUJOS-GUILLOT, Estelle | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0165-9936 | |
dc.description.abstractEn | Metabolomics is now a mature phenotyping tool that provides substantial results within various scientific communities. Its application at large-scale, i.e. on large populations and/or samples, has shown its power for research activities from plant science to human epidemiology and medicine, but it still needs key methodological developments for its routine application. Here, we review the current state of large-scale metabolomics applications, providing recent examples of large cohort studies in human and plant/environment research, and present the remaining scientific challenges of both fields. Then, we address the key common methodological issues, from analytics to data science, to fulfil these objectives and go towards a more comprehensive and interoperable large-scale metabolomics, making it a new key actor in the frame of the One-Health future research. | |
dc.description.sponsorship | Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation | |
dc.description.sponsorship | Centre français de phénomique végétale - ANR-11-INBS-0012 | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/ | |
dc.subject.en | Cohort | |
dc.subject.en | Data science | |
dc.subject.en | Interoperability | |
dc.subject.en | Large-scale | |
dc.subject.en | Mass spectrometry | |
dc.subject.en | Metabolomics | |
dc.subject.en | Nuclear magnetic resonance | |
dc.subject.en | One-health | |
dc.title.en | Scaling-up metabolomics: Current state and perspectives | |
dc.type | Article de revue | |
dc.type | Article de synthèse | |
dc.identifier.doi | 10.1016/j.trac.2023.117225 | |
dc.subject.hal | Chimie/Chimie analytique | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biologie végétale | |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | |
dc.description.sponsorshipEurope | summit | |
bordeaux.journal | Trends in Analytical Chemistry | |
bordeaux.page | 117225 | |
bordeaux.volume | 167 | |
bordeaux.issue | 20 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-04188505 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-04188505v1 | |
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