HAJJAR, Ghina; BARROS SANTOS, Millena Cristina; BERTRAND-MICHEL, Justine; CANLET, Cécile; CASTELLI, Florence; CREUSOT, Nicolas; DECHAUMET, Sylvain; DIÉMÉ, Binta; GIACOMONI, Franck; GIRAUDEAU, Patrick; GUITTON, Yann; THÉVENOT, Etienne A; TREMBLAY-FRANCO, Marie; JUNOT, Christophe; JOURDAN, Fabien; FENAILLE, François; COMTE, Blandine; PÉTRIACQ, Pierre; PUJOS-GUILLOT, Estelle

doi:10.1016/j.trac.2023.117225

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Licence d’utilisation du document

http://creativecommons.org/licenses/by-nc-nd/

HAJJAR, Ghina
Plateforme Exploration du Métabolisme [PFEM]

BARROS SANTOS, Millena Cristina
Plateforme Bordeaux Metabolome
Biologie du fruit et pathologie [BFP]

BERTRAND-MICHEL, Justine
Institut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]

Langue

Article de revue

Ce document a été publié dans

Trends in Analytical Chemistry. 2023, vol. 167, n° 20, p. 117225

Elsevier

Résumé en anglais

Metabolomics is now a mature phenotyping tool that provides substantial results within various scientific communities. Its application at large-scale, i.e. on large populations and/or samples, has shown its power for research activities from plant science to human epidemiology and medicine, but it still needs key methodological developments for its routine application. Here, we review the current state of large-scale metabolomics applications, providing recent examples of large cohort studies in human and plant/environment research, and present the remaining scientific challenges of both fields. Then, we address the key common methodological issues, from analytics to data science, to fulfil these objectives and go towards a more comprehensive and interoperable large-scale metabolomics, making it a new key actor in the frame of the One-Health future research.< Réduire

Mots clés en anglais

Cohort

Data science

Interoperability

Large-scale

Mass spectrometry

Metabolomics

Nuclear magnetic resonance

One-health

DOI

http://dx.doi.org/10.1016/j.trac.2023.117225

Projet Européen

summit

Project ANR

Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation
Centre français de phénomique végétale

Origine

Importé de hal

Unités de recherche

Biologie du Fruit & Pathologie (BFP) - UMR 1332