Secretion Systems Used by Bacteria to Subvert Host Functions.
FRONZES, Remi
Institut Européen de Chimie et Biologie [IECB]
Microbiologie Fondamentale et Pathogénicité [MFP]
Institute of Structural and Molecular Biology
Institut Européen de Chimie et Biologie [IECB]
Microbiologie Fondamentale et Pathogénicité [MFP]
Institute of Structural and Molecular Biology
FRONZES, Remi
Institut Européen de Chimie et Biologie [IECB]
Microbiologie Fondamentale et Pathogénicité [MFP]
Institute of Structural and Molecular Biology
< Réduire
Institut Européen de Chimie et Biologie [IECB]
Microbiologie Fondamentale et Pathogénicité [MFP]
Institute of Structural and Molecular Biology
Langue
EN
Article de revue
Ce document a été publié dans
Current Issues in Molecular Biology. 2018-01-01, vol. 25, p. 1-42
Résumé en anglais
In this review we examine the use of secretion systems by bacteria to subvert host functions. Bacteria have evolved multiple systems to interact with and overcome their eukaryotic host and other prokaryotes. Secretion ...Lire la suite >
In this review we examine the use of secretion systems by bacteria to subvert host functions. Bacteria have evolved multiple systems to interact with and overcome their eukaryotic host and other prokaryotes. Secretion systems are required for the release of several effectors through the bacterial membrane(s) into the extracellular space or directly into the cytoplasm of the host. We review the secretion systems of Gram-positive and Gram-negative bacteria and describe briefly the structural composition of the seven secretion systems that have been associated with increased virulence through subversion of host functions. Some of the effects of such systems on eukaryotic host processes have been studied extensively. We also describe the best-characterized effectors of each secretion system to give an overview of the molecular mechanisms employed by bacteria to hide from the immune system and convert eukaryotic cells into optimal ecological niches for their replication.< Réduire
Mots clés en anglais
Animals
Bacterial Proteins
Bacterial Secretion Systems
Eukaryotic Cells
Gene Expression Regulation
Bacterial
Gram-Negative Bacteria
Gram-Positive Bacteria
Host-Pathogen Interactions
Humans
Models
Molecular
Periplasm
Protein Structure
Secondary
Protein Transport
Virulence
Virulence Factors
Unités de recherche