VIOT, Benjamin; GARRIGUE, Isabelle; TATON, Benjamin; BACHELET, Thomas; MOREAU, Jean-Francois; DECHANET-MERVILLE, Julie; MERVILLE, Pierre; COUZI, Lionel

doi:10.1111/tid.12408

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VIOT, Benjamin
CHU de Bordeaux Pellegrin [Bordeaux]
Service de Néphrologie-transplantation-dialyse [Bordeaux]

GARRIGUE, Isabelle

Microbiologie Fondamentale et Pathogénicité [MFP]

TATON, Benjamin

Service de Néphrologie-Transplantation-Dialyse
CHU de Bordeaux Pellegrin [Bordeaux]

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Transplant Infectious Disease. 2015-08-01, vol. 17, n° 4, p. 497-509

Résumé en anglais

The incidence and the impact of asymptomatic cytomegalovirus (CMV) DNAemia occurring after the first year post transplantation is unknown. In this retrospective cross-sectional study, we analyzed the incidence, risk factors, and impact of 2-year post-transplantation asymptomatic CMV DNAemia (2YCD) on graft function. We included 892 consecutive asymptomatic kidney transplant recipients transplanted for at least 2 years and all were monitored using whole blood CMV quantitative nucleic acid amplification testing (CMV-QNAT). Twenty-eight patients displayed 2YCD (3.1%). Using multivariate analysis in 578 patients, we found that female gender (odds ratio [OR] = 2.57, P = 0.02), a past history of CMV drug-resistance mutation (OR = 8.73, P = 0.005), and corticosteroid use (OR = 2.37, P = 0.03) were independently associated with an increased risk of 2YCD. 2YCD was associated with an increased incidence of subsequent CMV disease over the year following its diagnosis (7% vs. 0.6%, P = 0.02). Patients with 2YCD also exhibited a declining estimated glomerular filtration rate more frequently (77%) than patients with a negative CMV-QNAT (56%, P = 0.02). 2YCD appears to be a rare entity, which appears to be associated with chronic graft dysfunction.< Réduire

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Aged

Asymptomatic Infections

Cross-Sectional Studies

Cytomegalovirus

Cytomegalovirus Infections

Female

Follow-Up Studies

Graft Survival

Humans

Incidence

Kidney Transplantation

Logistic Models

Male

Middle Aged

Outcome Assessment

Health Care

Postoperative Complications

Retrospective Studies

Risk Factors

Sex Factors

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Two-year post-transplantation cytomegalovirus DNAemia in asymptomatic kidney transplant recipients: incidence, risk factors, and outcome.

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