Afficher la notice abrégée

Two-year post-transplantation cytomegalovirus DNAemia in asymptomatic kidney transplant recipients: incidence, risk factors, and outcome.

dc.rights.licenseopenen_US
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
dc.contributor.authorVIOT, Benjamin
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorGARRIGUE, Isabelle
IDREF: 12258953X
hal.structure.identifierService de Néphrologie-Transplantation-Dialyse
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
dc.contributor.authorTATON, Benjamin
hal.structure.identifierCentre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorBACHELET, Thomas
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierService d'immunologie et d'immunogénétique [Bordeaux]
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorMOREAU, Jean-Francois
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorDECHANET-MERVILLE, Julie
IDREF: 061667994
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorMERVILLE, Pierre
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
hal.structure.identifierService de Néphrologie-transplantation-dialyse [Bordeaux]
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
dc.date.accessioned2023-11-20T13:49:30Z
dc.date.available2023-11-20T13:49:30Z
dc.date.issued2015-08-01
dc.identifier.issn1399-3062en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184850
dc.description.abstractEnThe incidence and the impact of asymptomatic cytomegalovirus (CMV) DNAemia occurring after the first year post transplantation is unknown. In this retrospective cross-sectional study, we analyzed the incidence, risk factors, and impact of 2-year post-transplantation asymptomatic CMV DNAemia (2YCD) on graft function. We included 892 consecutive asymptomatic kidney transplant recipients transplanted for at least 2 years and all were monitored using whole blood CMV quantitative nucleic acid amplification testing (CMV-QNAT). Twenty-eight patients displayed 2YCD (3.1%). Using multivariate analysis in 578 patients, we found that female gender (odds ratio [OR] = 2.57, P = 0.02), a past history of CMV drug-resistance mutation (OR = 8.73, P = 0.005), and corticosteroid use (OR = 2.37, P = 0.03) were independently associated with an increased risk of 2YCD. 2YCD was associated with an increased incidence of subsequent CMV disease over the year following its diagnosis (7% vs. 0.6%, P = 0.02). Patients with 2YCD also exhibited a declining estimated glomerular filtration rate more frequently (77%) than patients with a negative CMV-QNAT (56%, P = 0.02). 2YCD appears to be a rare entity, which appears to be associated with chronic graft dysfunction.
dc.language.isoENen_US
dc.subject.enAged
dc.subject.enAsymptomatic Infections
dc.subject.enCross-Sectional Studies
dc.subject.enCytomegalovirus
dc.subject.enCytomegalovirus Infections
dc.subject.enFemale
dc.subject.enFollow-Up Studies
dc.subject.enGraft Survival
dc.subject.enHumans
dc.subject.enIncidence
dc.subject.enKidney Transplantation
dc.subject.enLogistic Models
dc.subject.enMale
dc.subject.enMiddle Aged
dc.subject.enOutcome Assessment
dc.subject.enHealth Care
dc.subject.enPostoperative Complications
dc.subject.enRetrospective Studies
dc.subject.enRisk Factors
dc.subject.enSex Factors
dc.title.enTwo-year post-transplantation cytomegalovirus DNAemia in asymptomatic kidney transplant recipients: incidence, risk factors, and outcome.
dc.title.alternativeTranspl Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/tid.12408en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed26052675en_US
bordeaux.journalTransplant Infectious Diseaseen_US
bordeaux.page497-509en_US
bordeaux.volume17en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue4en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04295813
hal.version1
hal.date.transferred2023-11-20T13:49:32Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Transplant%20Infectious%20Disease&rft.date=2015-08-01&rft.volume=17&rft.issue=4&rft.spage=497-509&rft.epage=497-509&rft.eissn=1399-3062&rft.issn=1399-3062&rft.au=VIOT,%20Benjamin&GARRIGUE,%20Isabelle&TATON,%20Benjamin&BACHELET,%20Thomas&MOREAU,%20Jean-Francois&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée