Retroviral DNA Integration.
Idioma
EN
Article de revue
Este ítem está publicado en
Chemical Reviews. 2016-10-26, vol. 116, n° 20, p. 12730-12757
Resumen en inglés
The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among ...Leer más >
The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among retroviruses and LTR-retrotransposons. Retroviral integration proceeds via two integrase activities: 3'-processing of the viral DNA ends, followed by the strand transfer of the processed ends into host cell chromosomal DNA. Herein we review the molecular mechanism of retroviral DNA integration, with an emphasis on reaction chemistries and architectures of the nucleoprotein complexes involved. We additionally discuss the latest advances on anti-integrase drug development for the treatment of AIDS and the utility of integrating retroviral vectors in gene therapy applications.< Leer menos
Palabras clave en inglés
DNA Repair
DNA
Viral
Drug Design
HIV Integrase
HIV Integrase Inhibitors
HIV-1
Protein Conformation
Virus Integration
Centros de investigación