Retroviral DNA Integration.
Langue
EN
Article de revue
Ce document a été publié dans
Chemical Reviews. 2016-10-26, vol. 116, n° 20, p. 12730-12757
Résumé en anglais
The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among ...Lire la suite >
The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among retroviruses and LTR-retrotransposons. Retroviral integration proceeds via two integrase activities: 3'-processing of the viral DNA ends, followed by the strand transfer of the processed ends into host cell chromosomal DNA. Herein we review the molecular mechanism of retroviral DNA integration, with an emphasis on reaction chemistries and architectures of the nucleoprotein complexes involved. We additionally discuss the latest advances on anti-integrase drug development for the treatment of AIDS and the utility of integrating retroviral vectors in gene therapy applications.< Réduire
Mots clés en anglais
DNA Repair
DNA
Viral
Drug Design
HIV Integrase
HIV Integrase Inhibitors
HIV-1
Protein Conformation
Virus Integration
Unités de recherche