A system for in vivo on-demand ultra-low field Overhauser-enhanced 3D-Magnetic resonance imaging.
Language
EN
Article de revue
This item was published in
Journal of Magnetic Resonance. 2023-03-01, vol. 348, p. 107383
English Abstract
Development of very-low field MRI is an active area of research. It aims at reducing operating costs and improve portability. However, the signal-to-noise issue becomes prominent at ultra-low field (<1 mT), especially for ...Read more >
Development of very-low field MRI is an active area of research. It aims at reducing operating costs and improve portability. However, the signal-to-noise issue becomes prominent at ultra-low field (<1 mT), especially for molecular imaging purposes that addresses specific biochemical events. In the context of preclinical molecular MRI of abnormal proteolysis the paper describes a MRI system able to produce Overhauser-enhanced MR images in living rats through in situ Dynamic Nuclear Polarization at 206 µT using stable and non-toxic nitroxides. In parallel conventional images are generated at 206 µT following pre-polarization at 20 mT. Results show that nitroxides are visualized in 3D within a few minutes in the lungs, kidneys and bladder post-administration. This system will be used for molecular imaging of inflammation using protease-specific nitroxide probes.Read less <
English Keywords
Rats
Animals
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Lung
Nitrogen Oxides