BOUDRIES, Dahmane; MASSOT, Philippe; PARZY, Elodie; SEREN, Seda; MELLET, Philippe; FRANCONI, Jean-Michel; MIRAUX, Sylvain; BEZANÇON, Eric; MARQUE, Sylvain R A; AUDRAN, Gérard; MUETZEL, Markus; WINTZHEIMER, Stefan; FIDLER, Florian; THIAUDIERE, Eric

doi:10.1016/j.jmr.2023.107383

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BOUDRIES, Dahmane

Centre de résonance magnétique des systèmes biologiques [CRMSB]

MASSOT, Philippe
Centre de résonance magnétique des systèmes biologiques [CRMSB]

PARZY, Elodie

Centre de résonance magnétique des systèmes biologiques [CRMSB]

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Journal of Magnetic Resonance. 2023-03-01, vol. 348, p. 107383

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Development of very-low field MRI is an active area of research. It aims at reducing operating costs and improve portability. However, the signal-to-noise issue becomes prominent at ultra-low field (<1 mT), especially for molecular imaging purposes that addresses specific biochemical events. In the context of preclinical molecular MRI of abnormal proteolysis the paper describes a MRI system able to produce Overhauser-enhanced MR images in living rats through in situ Dynamic Nuclear Polarization at 206 µT using stable and non-toxic nitroxides. In parallel conventional images are generated at 206 µT following pre-polarization at 20 mT. Results show that nitroxides are visualized in 3D within a few minutes in the lungs, kidneys and bladder post-administration. This system will be used for molecular imaging of inflammation using protease-specific nitroxide probes.< Réduire

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Rats

Animals

Magnetic Resonance Spectroscopy

Magnetic Resonance Imaging

Lung

Nitrogen Oxides

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A system for in vivo on-demand ultra-low field Overhauser-enhanced 3D-Magnetic resonance imaging.

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