Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.
Langue
EN
Article de revue
Ce document a été publié dans
Biochimie. 2015-11-01, vol. 118, p. 173-5
Résumé en anglais
During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for ...Lire la suite >
During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trials as anticancer agent. Here, we show that AS1411 exhibits extremely potent antiviral activity and is therefore an attractive new lead as anti-HIV agent.< Réduire
Mots clés en anglais
Anti-HIV Agents
Antineoplastic Agents
Aptamers
Nucleotide
Cell Line
Cell Proliferation
HIV-1
Humans
Oligodeoxyribonucleotides
Unités de recherche