Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | METIFIOT, Mathieu | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| dc.contributor.author | AMRANE, Samir | |
| hal.structure.identifier | Institut Européen de Chimie et Biologie [IECB] | |
| dc.contributor.author | MERGNY, Jean-Louis | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | ANDREOLA, Marie-Line | |
| dc.date.accessioned | 2023-11-13T11:42:53Z | |
| dc.date.available | 2023-11-13T11:42:53Z | |
| dc.date.issued | 2015-11-01 | |
| dc.identifier.issn | 1638-6183 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184726 | |
| dc.description.abstractEn | During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trials as anticancer agent. Here, we show that AS1411 exhibits extremely potent antiviral activity and is therefore an attractive new lead as anti-HIV agent. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Anti-HIV Agents | |
| dc.subject.en | Antineoplastic Agents | |
| dc.subject.en | Aptamers | |
| dc.subject.en | Nucleotide | |
| dc.subject.en | Cell Line | |
| dc.subject.en | Cell Proliferation | |
| dc.subject.en | HIV-1 | |
| dc.subject.en | Humans | |
| dc.subject.en | Oligodeoxyribonucleotides | |
| dc.title.en | Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1. | |
| dc.title.alternative | Biochimie | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.biochi.2015.09.009 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 26363100 | en_US |
| bordeaux.journal | Biochimie | en_US |
| bordeaux.page | 173-5 | en_US |
| bordeaux.volume | 118 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04282124 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-11-13T11:42:55Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biochimie&rft.date=2015-11-01&rft.volume=118&rft.spage=173-5&rft.epage=173-5&rft.eissn=1638-6183&rft.issn=1638-6183&rft.au=METIFIOT,%20Mathieu&AMRANE,%20Samir&MERGNY,%20Jean-Louis&ANDREOLA,%20Marie-Line&rft.genre=article |
