SOULIÉ, Cathia; DESCAMPS, Diane; RONIQUE SCHNEIDER, Vé; TRABAUD, Mary-Anne; MORAND-JOUBERT, Laurence; DELAUGERRE, Constance; MONTES, Brigitte; BARIN, Francis; FERRÉ, Virginie; MAILLARD, Anne; VALLET, Sophie; ROUSSEL, Catherine; ASSOUMOU, Lambert; CALVEZ, Vincent; FLANDRE, Philippe; VE, Anne-Geneviè; JEULIN, H.; GUIGON, A.; LAGIER, E.; LE GUILLOU, H.; ALLOUI, C.; BETTINGER, D.; PALLIER, C.; FLEURY, H.; REIGADAS, S.; BELLECAVE, P.; RECORDON-PINSON, P.; PAYAN, C.; VABRET, A.; HENQUELL, C.; MIRAND, A.; BOUVIER-ALIAS, M.; DE ROUGEMONT, Alexis; DOS SANTOS, G.; MORAND, P.; SIGNORI-SCHMUCK, A.; BOCKET, L.; ROGEZ, S.; ANDRE, P.; TARDY, J.; TAMALET, C.; DELAMARE, C.; SCHVOERER, E.; ANDRÉ-GARNIER, E.; COTTALORDA, J.; GUINARD, J.; GUIGUON, A.; BRUN-VEZINET, F.; CHARPENTIER, C.; VISSEAUX, B.; PEYTAVIN, G.; KRIVINE, A.; SI-MOHAMED, A.; AVETTAND-FENOEL, V.; MARCELIN, A.-G.; LAMBERT-NICLOT, S.; WIRDEN, M.; CHAIX, M.; AMIEL, C.; SCHNEIDER, V.; GIRAUDEAU, G.; BRODARD, V.; PLANTIER, J.; CHAPLAIN, C.; BOURLET, T.; FAFI-KREMER, S.; STOLL-KELLER, F.; SCHMITT, M.; BARTH, H.; YERLY, S.; POGGI, C.; IZOPET, Jacques; RAYMOND, S.; CHAILLON, A.; MARQUE-JUILLET, S.; ROQUE-AFONSO, A.; HAIM-BOUKOBZA, S.; GRUDE, Maxime; COSTAGLIOLA, D.; ALLEGRE, T.; SCHMIT, J.; CHENNEBAULT, J.; BOUCHAUD, O.; MAGY-BERTRAND, N.; DELFRAISSY, J.; DUPON, M.; MORLAT, P.; NEAU, D.; ANSART, S.; JAFFUEL, S.; VERDON, R.; JACOMET, C.; LEVY, Y.; DOMINGUEZ, S.; CHAVANET, P.; PIROTH, L.; CABIÉ, A.; LECLERCQ, P.; AJANA, F.; CHERET, A.; WEINBRECK, P.; COTTE, L.; POIZOT-MARTIN, I.; RAVAUD, I.; CHRISTIAN, B.; TRUCHETET, F.; GRANDIDIER, M.; REYNES, J.; MAY, T.; GOEHRINGER, F.; RAFFI, F.; DELLAMONICA, P.; PRAZUCK, T.; HOCQUELOUX, L.; YENI, P.; LANDMAN, R.; LAUNAY, O.; WEISS, L.; VIARD, J.; KATLAMA, C.; SIMON, A.; GIRARD, Pascal; MEYNARD, J.; MOLINA, J.; PIALOUX, G.; HOEN, B.; GOEGER-SOW, M.; LAMAURY, I.; BEAUCAIRE, G.; JAUSSAUD, R.; ROUGER, C.; MICHELET, C.; BORSA-LEBAS, F.; CARON, F.; KHUONG, M.; LUCHT, F.; REY, D.; CALMY, A.; MARCHOU, B.; GRAS, G.; GREDER-BELAN, A.; VITTECOQ, D.; TEICHER, E.

doi:10.1093/jac/dku419

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2015-01-12, vol. 70, n° 2, p. 566-572

Résumé en anglais

Objectives: The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods: Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were .50 copies/mL in both compartments and bulk genotypic tests were realized. Results: On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (P ¼ 0.0455) and T215Y (P ¼0.0455). Conclusions: In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performed.< Réduire

Mots clés en anglais

ARV

HIV

resistance

CSF

URI

https://oskar-bordeaux.fr/handle/20.500.12278/183412

DOI

http://dx.doi.org/10.1093/jac/dku419

Unités de recherche

MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

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Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma

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Résumé en anglais

Mots clés en anglais

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