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Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma

dc.rights.licenseopenen_US
dc.contributor.authorSOULIÉ, Cathia
dc.contributor.authorDESCAMPS, Diane
dc.contributor.authorRONIQUE SCHNEIDER, Vé
dc.contributor.authorTRABAUD, Mary-Anne
dc.contributor.authorMORAND-JOUBERT, Laurence
dc.contributor.authorDELAUGERRE, Constance
dc.contributor.authorMONTES, Brigitte
dc.contributor.authorBARIN, Francis
dc.contributor.authorFERRÉ, Virginie
dc.contributor.authorMAILLARD, Anne
dc.contributor.authorVALLET, Sophie
dc.contributor.authorROUSSEL, Catherine
dc.contributor.authorASSOUMOU, Lambert
dc.contributor.authorCALVEZ, Vincent
dc.contributor.authorFLANDRE, Philippe
dc.contributor.authorVE, Anne-Geneviè
dc.contributor.authorJEULIN, H.
dc.contributor.authorGUIGON, A.
dc.contributor.authorLAGIER, E.
dc.contributor.authorLE GUILLOU, H.
dc.contributor.authorALLOUI, C.
dc.contributor.authorBETTINGER, D.
dc.contributor.authorPALLIER, C.
dc.contributor.authorFLEURY, H.
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorREIGADAS, S.
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBELLECAVE, P.
dc.contributor.authorRECORDON-PINSON, P.
dc.contributor.authorPAYAN, C.
dc.contributor.authorVABRET, A.
dc.contributor.authorHENQUELL, C.
dc.contributor.authorMIRAND, A.
dc.contributor.authorBOUVIER-ALIAS, M.
dc.contributor.authorDE ROUGEMONT, Alexis
dc.contributor.authorDOS SANTOS, G.
dc.contributor.authorMORAND, P.
dc.contributor.authorSIGNORI-SCHMUCK, A.
dc.contributor.authorBOCKET, L.
dc.contributor.authorROGEZ, S.
dc.contributor.authorANDRE, P.
dc.contributor.authorTARDY, J.
dc.contributor.authorTAMALET, C.
dc.contributor.authorDELAMARE, C.
dc.contributor.authorSCHVOERER, E.
dc.contributor.authorANDRÉ-GARNIER, E.
dc.contributor.authorCOTTALORDA, J.
dc.contributor.authorGUINARD, J.
dc.contributor.authorGUIGUON, A.
dc.contributor.authorBRUN-VEZINET, F.
dc.contributor.authorCHARPENTIER, C.
dc.contributor.authorVISSEAUX, B.
dc.contributor.authorPEYTAVIN, G.
dc.contributor.authorKRIVINE, A.
dc.contributor.authorSI-MOHAMED, A.
dc.contributor.authorAVETTAND-FENOEL, V.
dc.contributor.authorMARCELIN, A.-G.
dc.contributor.authorLAMBERT-NICLOT, S.
dc.contributor.authorWIRDEN, M.
dc.contributor.authorCHAIX, M.
dc.contributor.authorAMIEL, C.
dc.contributor.authorSCHNEIDER, V.
dc.contributor.authorGIRAUDEAU, G.
dc.contributor.authorBRODARD, V.
dc.contributor.authorPLANTIER, J.
dc.contributor.authorCHAPLAIN, C.
dc.contributor.authorBOURLET, T.
dc.contributor.authorFAFI-KREMER, S.
dc.contributor.authorSTOLL-KELLER, F.
dc.contributor.authorSCHMITT, M.
dc.contributor.authorBARTH, H.
dc.contributor.authorYERLY, S.
dc.contributor.authorPOGGI, C.
dc.contributor.authorIZOPET, Jacques
dc.contributor.authorRAYMOND, S.
dc.contributor.authorCHAILLON, A.
dc.contributor.authorMARQUE-JUILLET, S.
dc.contributor.authorROQUE-AFONSO, A.
dc.contributor.authorHAIM-BOUKOBZA, S.
dc.contributor.authorGRUDE, Maxime
dc.contributor.authorCOSTAGLIOLA, D.
dc.contributor.authorALLEGRE, T.
dc.contributor.authorSCHMIT, J.
dc.contributor.authorCHENNEBAULT, J.
dc.contributor.authorBOUCHAUD, O.
dc.contributor.authorMAGY-BERTRAND, N.
dc.contributor.authorDELFRAISSY, J.
hal.structure.identifierCHU Bordeaux
dc.contributor.authorDUPON, M.
dc.contributor.authorMORLAT, P.
hal.structure.identifierFédération des Maladies Infectieuses [Bordeaux]
dc.contributor.authorNEAU, D.
dc.contributor.authorANSART, S.
dc.contributor.authorJAFFUEL, S.
dc.contributor.authorVERDON, R.
dc.contributor.authorJACOMET, C.
dc.contributor.authorLEVY, Y.
dc.contributor.authorDOMINGUEZ, S.
hal.structure.identifierCHU Dijon
dc.contributor.authorCHAVANET, P.
dc.contributor.authorPIROTH, L.
dc.contributor.authorCABIÉ, A.
dc.contributor.authorLECLERCQ, P.
dc.contributor.authorAJANA, F.
dc.contributor.authorCHERET, A.
dc.contributor.authorWEINBRECK, P.
dc.contributor.authorCOTTE, L.
dc.contributor.authorPOIZOT-MARTIN, I.
dc.contributor.authorRAVAUD, I.
dc.contributor.authorCHRISTIAN, B.
dc.contributor.authorTRUCHETET, F.
dc.contributor.authorGRANDIDIER, M.
dc.contributor.authorREYNES, J.
dc.contributor.authorMAY, T.
dc.contributor.authorGOEHRINGER, F.
dc.contributor.authorRAFFI, F.
dc.contributor.authorDELLAMONICA, P.
dc.contributor.authorPRAZUCK, T.
dc.contributor.authorHOCQUELOUX, L.
dc.contributor.authorYENI, P.
dc.contributor.authorLANDMAN, R.
dc.contributor.authorLAUNAY, O.
dc.contributor.authorWEISS, L.
dc.contributor.authorVIARD, J.
dc.contributor.authorKATLAMA, C.
dc.contributor.authorSIMON, A.
dc.contributor.authorGIRARD, Pascal
dc.contributor.authorMEYNARD, J.
dc.contributor.authorMOLINA, J.
dc.contributor.authorPIALOUX, G.
dc.contributor.authorHOEN, B.
dc.contributor.authorGOEGER-SOW, M.
dc.contributor.authorLAMAURY, I.
dc.contributor.authorBEAUCAIRE, G.
dc.contributor.authorJAUSSAUD, R.
dc.contributor.authorROUGER, C.
dc.contributor.authorMICHELET, C.
dc.contributor.authorBORSA-LEBAS, F.
dc.contributor.authorCARON, F.
dc.contributor.authorKHUONG, M.
dc.contributor.authorLUCHT, F.
hal.structure.identifierCentre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
dc.contributor.authorREY, D.
dc.contributor.authorCALMY, A.
dc.contributor.authorMARCHOU, B.
dc.contributor.authorGRAS, G.
dc.contributor.authorGREDER-BELAN, A.
dc.contributor.authorVITTECOQ, D.
dc.contributor.authorTEICHER, E.
dc.date.accessioned2023-07-18T07:42:30Z
dc.date.available2023-07-18T07:42:30Z
dc.date.issued2015-01-12
dc.identifier.issn0305-7453en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/183412
dc.description.abstractEnObjectives: The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods: Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were .50 copies/mL in both compartments and bulk genotypic tests were realized. Results: On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (P ¼ 0.0455) and T215Y (P ¼0.0455). Conclusions: In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performed.
dc.language.isoENen_US
dc.subject.enARV
dc.subject.enHIV
dc.subject.enresistance
dc.subject.enCSF
dc.title.enAntiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/jac/dku419en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologieen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieusesen_US
bordeaux.page566-572en_US
bordeaux.volume70en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue2en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-02291062
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
workflow.import.sourcehal
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