Glycosomes: A comprehensive view of their metabolic roles in T. brucei
Langue
en
Article de revue
Ce document a été publié dans
International Journal of Biochemistry and Cell Biology. 2017, vol. 85, p. 85-90
Elsevier
Résumé en anglais
Peroxisomes are single-membrane cellular organelles, present in most eukaryotic cells and organisms from human to yeast, fulfilling essential metabolic functions in lipid metabolism, free radical detoxification, differentiation, ...Lire la suite >
Peroxisomes are single-membrane cellular organelles, present in most eukaryotic cells and organisms from human to yeast, fulfilling essential metabolic functions in lipid metabolism, free radical detoxification, differentiation, development, morphogenesis, etc. Interestingly, the protozoan parasite species Trypanosoma contains peroxisome-like organelles named glycosomes, which lack hallmark peroxisomal pathways and enzymes, such as catalase. Glycosomes are the only peroxisome-like organelles containing most enzymatic steps of the glycolytic pathway as well as enzymes of pyrimidine biosynthesis, purine salvage and biosynthesis of nucleotide sugars. We present here an overview of the glycosomal metabolic peculiarities together with the current view of the raison d'être of this unique metabolic peroxisomal sequestration.< Réduire
Mots clés en anglais
Peroxisome-like organelle
Glycolysis and gluconeogenesis
Purine and pyrimidine biosynthesis
ATP/ADP and NAD/NADH glycosomal balances
Glycosome
Projet Européen
A systematic analysis of parasite metabolism - from metabolism to intervention
Project ANR
Voies métaboliques glycosomales non glycolytiques: nouvelles fonctions pour le développement et la virulence des trypanosomes - ANR-15-CE15-0025
Interactions métaboliques entre les adipocytes et les trypanosomes, un nouveau paradigme pour les trypanosomoses - ANR-19-CE15-0004
Alliance française contre les maladies parasitaires - ANR-11-LABX-0024
Interactions métaboliques entre les adipocytes et les trypanosomes, un nouveau paradigme pour les trypanosomoses - ANR-19-CE15-0004
Alliance française contre les maladies parasitaires - ANR-11-LABX-0024
Unités de recherche