Glycosomes: A comprehensive view of their metabolic roles in T. brucei
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | ALLMANN, Stefan | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | BRINGAUD, Frédéric | |
| dc.date.accessioned | 2023-06-28T11:02:05Z | |
| dc.date.available | 2023-06-28T11:02:05Z | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 1357-2725 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/183223 | |
| dc.description.abstractEn | Peroxisomes are single-membrane cellular organelles, present in most eukaryotic cells and organisms from human to yeast, fulfilling essential metabolic functions in lipid metabolism, free radical detoxification, differentiation, development, morphogenesis, etc. Interestingly, the protozoan parasite species Trypanosoma contains peroxisome-like organelles named glycosomes, which lack hallmark peroxisomal pathways and enzymes, such as catalase. Glycosomes are the only peroxisome-like organelles containing most enzymatic steps of the glycolytic pathway as well as enzymes of pyrimidine biosynthesis, purine salvage and biosynthesis of nucleotide sugars. We present here an overview of the glycosomal metabolic peculiarities together with the current view of the raison d'être of this unique metabolic peroxisomal sequestration. | |
| dc.description.sponsorship | Voies métaboliques glycosomales non glycolytiques: nouvelles fonctions pour le développement et la virulence des trypanosomes - ANR-15-CE15-0025 | |
| dc.description.sponsorship | Interactions métaboliques entre les adipocytes et les trypanosomes, un nouveau paradigme pour les trypanosomoses - ANR-19-CE15-0004 | |
| dc.description.sponsorship | Alliance française contre les maladies parasitaires - ANR-11-LABX-0024 | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.subject.en | Peroxisome-like organelle | |
| dc.subject.en | Glycolysis and gluconeogenesis | |
| dc.subject.en | Purine and pyrimidine biosynthesis | |
| dc.subject.en | ATP/ADP and NAD/NADH glycosomal balances | |
| dc.subject.en | Glycosome | |
| dc.title.en | Glycosomes: A comprehensive view of their metabolic roles in T. brucei | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.biocel.2017.01.015 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologie | |
| dc.description.sponsorshipEurope | A systematic analysis of parasite metabolism - from metabolism to intervention | |
| bordeaux.journal | International Journal of Biochemistry and Cell Biology | en_US |
| bordeaux.page | 85-90 | |
| bordeaux.volume | 85 | |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| bordeaux.import.source | hal | |
| hal.identifier | hal-02348137 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
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