PLANCHE, Vincent; SU, Jason H.; MOURNET, Sandy; SARANATHAN, Manojkumar; DOUSSET, Vincent; HAN, May; RUTT, Brian K.; TOURDIAS, Thomas

doi:10.1177/1352458519828297

Voir/Ouvrir

MAGENDIE_ MultScler_2020_Planche.pdf (257.1Ko)

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

PLANCHE, Vincent
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]

SU, Jason H.
Stanford University

MOURNET, Sandy
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]

Langue

Document de travail - Pré-publication

Ce document a été publié dans

p. 987-992

Résumé en anglais

Background: Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging. Methods: White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients (n = 15) and matched controls (n = 12). Thalamic lesions were counted in individual sequences and lesion contrast-to-noise ratio (CNR) was measured. Volumes of 12 thalamic nuclei were measured using an automatic segmentation pipeline specifically developed for WMn-MPRAGE. Results: WMn-MPRAGE showed more thalamic MS lesions (n = 35 in 9 out of 15 patients) than MP-FLAIR (n = 25) and standard T1 (n = 23), which was associated with significant improvement of CNR (p < 0.0001). MS patients had whole thalamus atrophy (p = 0.003) with lower volumes found for the anteroventral (p < 0.001), the pulvinar (p < 0.0001), and the habenular (p = 0.004) nuclei. Conclusion: WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy. © The Author(s), 2019.< Réduire

Mots clés en anglais

Thalamic nuclei

Multiple sclerosis

Multi-atlas segmentation

White matter nulled MPRAGE

Ultra-high field MRI

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182738

DOI

http://dx.doi.org/10.1177/1352458519828297

Project ANR

Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043

Voir/Ouvrir

Métadonnées

Licence d’utilisation du document

White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Project ANR

Unités de recherche

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Project ANR

Unités de recherche