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dc.rights.licenseopenen_US
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorPLANCHE, Vincent
hal.structure.identifierStanford University
dc.contributor.authorSU, Jason H.
hal.structure.identifierCHU Bordeaux
dc.contributor.authorMOURNET, Sandy
hal.structure.identifierUniversity of Arizona
dc.contributor.authorSARANATHAN, Manojkumar
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDOUSSET, Vincent
hal.structure.identifierStanford School of Medicine [Stanford]
dc.contributor.authorHAN, May
hal.structure.identifierStanford University
dc.contributor.authorRUTT, Brian K.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTOURDIAS, Thomas
dc.date
dc.date.accessioned2023-06-21T11:51:57Z
dc.date.available2023-06-21T11:51:57Z
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/182738
dc.description.abstractEnBackground: Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging. Methods: White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients (n = 15) and matched controls (n = 12). Thalamic lesions were counted in individual sequences and lesion contrast-to-noise ratio (CNR) was measured. Volumes of 12 thalamic nuclei were measured using an automatic segmentation pipeline specifically developed for WMn-MPRAGE. Results: WMn-MPRAGE showed more thalamic MS lesions (n = 35 in 9 out of 15 patients) than MP-FLAIR (n = 25) and standard T1 (n = 23), which was associated with significant improvement of CNR (p < 0.0001). MS patients had whole thalamus atrophy (p = 0.003) with lower volumes found for the anteroventral (p < 0.001), the pulvinar (p < 0.0001), and the habenular (p = 0.004) nuclei. Conclusion: WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy. © The Author(s), 2019.
dc.description.sponsorshipTranslational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.language.isoENen_US
dc.subject.enThalamic nuclei
dc.subject.enMultiple sclerosis
dc.subject.enMulti-atlas segmentation
dc.subject.enWhite matter nulled MPRAGE
dc.subject.enUltra-high field MRI
dc.title.enWhite-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis
dc.title.alternativeMult Scleren_US
dc.typeDocument de travail - Pré-publicationen_US
dc.identifier.doi10.1177/1352458519828297en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed30730233en_US
bordeaux.page987-992en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamRelations glie-neuroneen_US
bordeaux.identifier.funderIDFondation pour l'Aide à la Recherche sur la Sclérose en Plaquesen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.spage=987-992&amp;rft.epage=987-992&amp;rft.au=PLANCHE,%20Vincent&amp;SU,%20Jason%20H.&amp;MOURNET,%20Sandy&amp;SARANATHAN,%20Manojkumar&amp;DOUSSET,%20Vincent&amp;rft.genre=preprint


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