Endocrine-disrupting chemicals and behaviour: A high risk to take?
BAKOYIANNIS, Ioannis
National and Kapodistrian University of Athens [NKUA]
Nutrition et Neurobiologie intégrée [NutriNeuro]
National and Kapodistrian University of Athens [NKUA]
Nutrition et Neurobiologie intégrée [NutriNeuro]
BAKOYIANNIS, Ioannis
National and Kapodistrian University of Athens [NKUA]
Nutrition et Neurobiologie intégrée [NutriNeuro]
< Reduce
National and Kapodistrian University of Athens [NKUA]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Language
EN
Article de revue
This item was published in
Best Practice & Research Clinical Endocrinology & Metabolism. 2021-09-01, vol. 35, n° 5, p. 101517
English Abstract
Early life exposure to endocrine-disrupting chemicals (EDCs) is considered a potential risk factor for aberrant brain development and the emergence of behavioral deficits. The purpose of this review is to summarize the ...Read more >
Early life exposure to endocrine-disrupting chemicals (EDCs) is considered a potential risk factor for aberrant brain development and the emergence of behavioral deficits. The purpose of this review is to summarize the toxic effects of bisphenol-A (BPA) and phthalate exposure during pre-, -post- or perinatal life on different types of behaviour in male and female rodents. Despite results not being always consistent, most probably due to methodological issues, it is highly probable that early life exposure to BPA or/and phthalates, affects various aspects of behaviour in the offspring. Adverse effects include: Increased levels of anxiety, altered exploratory behaviour, reduced social interaction or increased aggression and deficits in spatial or recognition learning and memory. These effects have been observed with a wide range of doses, in some cases even below the currently employed Tolerable Daily Intake dose for either BPA or phthalates.Read less <
English Keywords
anxiety
BPA
endocrine disruptors
memory
phthalate
social behavior