JEANNETEAU, Freddy; MEIJER, Onno C.; MOISAN, Marie  Pierre

doi:10.1111/jne.13203

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JEANNETEAU, Freddy

MEIJER, Onno C.

MOISAN, Marie Pierre

Nutrition et Neurobiologie intégrée [NutriNeuro]

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Article de revue

Ce document a été publié dans

Journal of Neuroendocrinology. 2023-02, vol. 35, n° 2, p. e13203

Résumé en anglais

Dissociation between the healthy and toxic effects of cortisol, a major stress-responding hormone has been a widely used strategy to develop anti-inflammatory glucocorticoids with fewer side effects. Such strategy falls short when treating brain disorders as timing and activity state within large-scale neuronal networks determine the physiological and behavioral specificity of cortisol response. Advances in structural molecular dynamics posit the bases for engineering glucocorticoids with precision bias for select downstream signaling pathways. Design of allosteric and/or cooperative control for the glucocorticoid receptor could help promote the beneficial and reduce the deleterious effects of cortisol on brain and behavior in disease conditions.< Réduire

Mots clés en anglais

allostery

biased signaling

cooperativity

drug discovery

nuclear receptors

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182476

DOI

http://dx.doi.org/10.1111/jne.13203

Project ANR

Mémoire des Adolescents Obeses: Influences des Rythmes circadiens - ANR-21-CE14-0086

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286