Structural basis of glucocorticoid receptor signaling bias
| dc.rights.license | open | en_US |
| dc.contributor.author | JEANNETEAU, Freddy | |
| dc.contributor.author | MEIJER, Onno C. | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MOISAN, Marie Pierre
IDREF: 060242264 | |
| dc.date.accessioned | 2023-06-05T09:16:13Z | |
| dc.date.available | 2023-06-05T09:16:13Z | |
| dc.date.issued | 2023-02 | |
| dc.identifier.issn | 1365-2826 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/182476 | |
| dc.description.abstractEn | Dissociation between the healthy and toxic effects of cortisol, a major stress-responding hormone has been a widely used strategy to develop anti-inflammatory glucocorticoids with fewer side effects. Such strategy falls short when treating brain disorders as timing and activity state within large-scale neuronal networks determine the physiological and behavioral specificity of cortisol response. Advances in structural molecular dynamics posit the bases for engineering glucocorticoids with precision bias for select downstream signaling pathways. Design of allosteric and/or cooperative control for the glucocorticoid receptor could help promote the beneficial and reduce the deleterious effects of cortisol on brain and behavior in disease conditions. | |
| dc.description.sponsorship | Mémoire des Adolescents Obeses: Influences des Rythmes circadiens - ANR-21-CE14-0086 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | allostery | |
| dc.subject.en | biased signaling | |
| dc.subject.en | cooperativity | |
| dc.subject.en | drug discovery | |
| dc.subject.en | nuclear receptors | |
| dc.title.en | Structural basis of glucocorticoid receptor signaling bias | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/jne.13203 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 36221223 | en_US |
| bordeaux.journal | Journal of Neuroendocrinology | en_US |
| bordeaux.page | e13203 | en_US |
| bordeaux.volume | 35 | en_US |
| bordeaux.hal.laboratories | NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Neuroendocrinology&rft.date=2023-02&rft.volume=35&rft.issue=2&rft.spage=e13203&rft.epage=e13203&rft.eissn=1365-2826&rft.issn=1365-2826&rft.au=JEANNETEAU,%20Freddy&MEIJER,%20Onno%20C.&MOISAN,%20Marie%20%20Pierre&rft.genre=article |
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