A Bottom‐Up Approach to Red‐Emitting Molecular‐Based Nanoparticles with Natural Stealth Properties and their Use for Single‐Particle Tracking Deep in Brain Tissue
Language
en
Article de revue
This item was published in
Advanced Materials. 2021-04-22, vol. 33, n° 22, p. 2006644
Wiley-VCH Verlag
English Abstract
Fluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and ...Read more >
Fluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and photostability, small size (on the scale of subcellular structures), biocompatibility, high brightness, and good solubility. The latter is a major challenge for inorganic nanoparticles, which require surface coating to be made water soluble. Molecular-based fluorescent organic nanoparticles (FONs) may prove a promising, spontaneously water-soluble alternative, whose bottom-up design allows for the fine-tuning of individual properties. Here, the critical challenge of controlling the interaction of nanoparticles with cellular membranes is addressed. This is a report on bright, size-tunable, red-emitting, naturally stealthy FONs that do not require the use of antifouling agents to impede interactions with cellular membranes. As a proof of concept, single FONs diffusing up to 150 µm deep in brain tissue are imaged and tracked.Read less <
European Project
Functionalisation of ultra-bright all organic nanoparticles for super resolution imaging in intact brain preparations
Combining carbon nanotubes and gold nanorods to investigate the extracellular space around synapses during neuronal communication
Combining carbon nanotubes and gold nanorods to investigate the extracellular space around synapses during neuronal communication
ANR Project
Regulation physiopathologique de la dynamique des recepteurs NMDA dans l'hippocampe - ANR-15-CE16-0004
Origin
Hal imported