ROSENDALE, Morgane; FLORES, Jessica; PAVIOLO, Chiara; PAGANO, Paolo; DANIEL, Jonathan; FERREIRA, Joana; VERLHAC, Jean‐baptiste; GROC, Laurent; COGNET, Laurent; BLANCHARD‐DESCE, Mireille

doi:10.1002/adma.202006644

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ROSENDALE, Morgane
Institut des Sciences Moléculaires [ISM]

FLORES, Jessica
Institut des Sciences Moléculaires [ISM]

PAVIOLO, Chiara
Laboratoire Photonique, Numérique et Nanosciences [LP2N]

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Article de revue

Ce document a été publié dans

Advanced Materials. 2021-04-22, vol. 33, n° 22, p. 2006644

Wiley-VCH Verlag

Résumé en anglais

Fluorescent nanoparticles dedicated to bioimaging applications should possess specific properties that have to be maintained in the aqueous, reactive, and crowded biological environment. These include chemical and photostability, small size (on the scale of subcellular structures), biocompatibility, high brightness, and good solubility. The latter is a major challenge for inorganic nanoparticles, which require surface coating to be made water soluble. Molecular-based fluorescent organic nanoparticles (FONs) may prove a promising, spontaneously water-soluble alternative, whose bottom-up design allows for the fine-tuning of individual properties. Here, the critical challenge of controlling the interaction of nanoparticles with cellular membranes is addressed. This is a report on bright, size-tunable, red-emitting, naturally stealthy FONs that do not require the use of antifouling agents to impede interactions with cellular membranes. As a proof of concept, single FONs diffusing up to 150 µm deep in brain tissue are imaged and tracked.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/181509

DOI

http://dx.doi.org/10.1002/adma.202006644

Projet Européen

Functionalisation of ultra-bright all organic nanoparticles for super resolution imaging in intact brain preparations
Combining carbon nanotubes and gold nanorods to investigate the extracellular space around synapses during neuronal communication

Project ANR

Regulation physiopathologique de la dynamique des recepteurs NMDA dans l'hippocampe - ANR-15-CE16-0004

Origine

Importé de hal

Unités de recherche

Laboratoire Photonique, Numérique et Nanosciences (LP2N) - UMR 5298