NEUFFER, Jeanne; GONZALEZ-DOMINGUEZ, Raul; LEFEVRE ARBOGAST, Sophie; LOW, Dorrain Y.; DRIOLLET, Benedicte; HELMER, Catherine; DU PREEZ, Andrea; DE LUCIA, Chiara; RUIGROK, Silvie R.; ALTENDORFER, Barbara; AIGNER, Ludwig; LUCASSEN, Paul J.; KOROSI, Aniko; THURET, Sandrine; MANACH, Claudine; PALLAS, Merce; URPI-SARDA, Mireia; SANCHEZ-PLA, Alex; ANDRES-LACUEVA, Cristina; SAMIERI, Cecilia

doi:10.3390/nu14214688

Bordeaux population health [BPH]

GONZALEZ-DOMINGUEZ, Raul

LEFEVRE ARBOGAST, Sophie

Bordeaux population health [BPH]

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Article de revue

Ce document a été publié dans

Nutrients. 2022-11-05, vol. 14, n° 21

Résumé en anglais

The gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut-brain axis, signal to the brain and influence cognition. Human studies have so far had limited success in identifying early metabolic alterations linked to cognitive aging, likely due to limitations in metabolite coverage or follow-ups. Older persons from the Three-City population-based cohort who had not been diagnosed with dementia at the time of blood sampling were included, and repeated measures of cognition over 12 subsequent years were collected. Using a targeted metabolomics platform, we identified 72 circulating gut-derived metabolites in a case-control study on cognitive decline, nested within the cohort (discovery n = 418; validation n = 420). Higher serum levels of propionic acid, a short-chain fatty acid, were associated with increased odds of cognitive decline (OR for 1 SD = 1.40 (95% CI 1.11, 1.75) for discovery and 1.26 (1.02, 1.55) for validation). Additional analyses suggested mediation by hypercholesterolemia and diabetes. Propionic acid strongly correlated with blood glucose (r = 0.79) and with intakes of meat and cheese (r > 0.15), but not fiber (r = 0.04), suggesting a minor role of prebiotic foods per se, but a possible link to processed foods, in which propionic acid is a common preservative. The adverse impact of propionic acid on metabolism and cognition deserves further investigation.< Réduire

Mots clés en anglais

Propionic acid

Gut microbiota

Metabolomics

Cognitive decline

Gut-brain axis

Alzheimer’s disease

Dementia

URI

https://oskar-bordeaux.fr/handle/20.500.12278/171989

DOI

http://dx.doi.org/10.3390/nu14214688

Project ANR

COGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005
Histoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé - ANR-07-LVIE-0003

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Exploration of the Gut-Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons