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Exploration of the Gut-Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNEUFFER, Jeanne
ORCID: 0000-0002-3667-6948
dc.contributor.authorGONZALEZ-DOMINGUEZ, Raul
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE ARBOGAST, Sophie
dc.contributor.authorLOW, Dorrain Y.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDRIOLLET, Benedicte
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorDU PREEZ, Andrea
dc.contributor.authorDE LUCIA, Chiara
dc.contributor.authorRUIGROK, Silvie R.
dc.contributor.authorALTENDORFER, Barbara
dc.contributor.authorAIGNER, Ludwig
dc.contributor.authorLUCASSEN, Paul J.
dc.contributor.authorKOROSI, Aniko
dc.contributor.authorTHURET, Sandrine
dc.contributor.authorMANACH, Claudine
dc.contributor.authorPALLAS, Merce
dc.contributor.authorURPI-SARDA, Mireia
dc.contributor.authorSANCHEZ-PLA, Alex
dc.contributor.authorANDRES-LACUEVA, Cristina
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.date.accessioned2023-02-20T09:50:27Z
dc.date.available2023-02-20T09:50:27Z
dc.date.issued2022-11-05
dc.identifier.issn2072-6643 (Electronic) 2072-6643 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/171989
dc.description.abstractEnThe gut microbiome is involved in nutrient metabolism and produces metabolites that, via the gut-brain axis, signal to the brain and influence cognition. Human studies have so far had limited success in identifying early metabolic alterations linked to cognitive aging, likely due to limitations in metabolite coverage or follow-ups. Older persons from the Three-City population-based cohort who had not been diagnosed with dementia at the time of blood sampling were included, and repeated measures of cognition over 12 subsequent years were collected. Using a targeted metabolomics platform, we identified 72 circulating gut-derived metabolites in a case-control study on cognitive decline, nested within the cohort (discovery n = 418; validation n = 420). Higher serum levels of propionic acid, a short-chain fatty acid, were associated with increased odds of cognitive decline (OR for 1 SD = 1.40 (95% CI 1.11, 1.75) for discovery and 1.26 (1.02, 1.55) for validation). Additional analyses suggested mediation by hypercholesterolemia and diabetes. Propionic acid strongly correlated with blood glucose (r = 0.79) and with intakes of meat and cheese (r > 0.15), but not fiber (r = 0.04), suggesting a minor role of prebiotic foods per se, but a possible link to processed foods, in which propionic acid is a common preservative. The adverse impact of propionic acid on metabolism and cognition deserves further investigation.
dc.description.sponsorshipCOGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005en_US
dc.description.sponsorshipHistoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé - ANR-07-LVIE-0003en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enPropionic acid
dc.subject.enGut microbiota
dc.subject.enMetabolomics
dc.subject.enCognitive decline
dc.subject.enGut-brain axis
dc.subject.enAlzheimer’s disease
dc.subject.enDementia
dc.title.enExploration of the Gut-Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons
dc.title.alternativeNutrientsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/nu14214688en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36364950en_US
bordeaux.journalNutrientsen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue21en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03996746
hal.version1
hal.date.transferred2023-02-20T09:50:32Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nutrients&rft.date=2022-11-05&rft.volume=14&rft.issue=21&rft.eissn=2072-6643%20(Electronic)%202072-6643%20(Linking)&rft.issn=2072-6643%20(Electronic)%202072-6643%20(Linking)&rft.au=NEUFFER,%20Jeanne&GONZALEZ-DOMINGUEZ,%20Raul&LEFEVRE%20ARBOGAST,%20Sophie&LOW,%20Dorrain%20Y.&DRIOLLET,%20Benedicte&rft.genre=article


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