A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes
SEAL, Snehaa
Université du Luxembourg = University of Luxembourg = Universität Luxemburg [uni.lu]
Luxembourg Institute of Health [LIH]
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Université du Luxembourg = University of Luxembourg = Universität Luxemburg [uni.lu]
Luxembourg Institute of Health [LIH]
SEAL, Snehaa
Université du Luxembourg = University of Luxembourg = Universität Luxemburg [uni.lu]
Luxembourg Institute of Health [LIH]
Université du Luxembourg = University of Luxembourg = Universität Luxemburg [uni.lu]
Luxembourg Institute of Health [LIH]
HOLUKA, Cyrielle
Université du Luxembourg = University of Luxembourg = Universität Luxemburg [uni.lu]
Luxembourg Institute of Health [LIH]
< Réduire
Université du Luxembourg = University of Luxembourg = Universität Luxemburg [uni.lu]
Luxembourg Institute of Health [LIH]
Langue
EN
Article de revue
Ce document a été publié dans
Frontiers in immunology. 2022-05-23, vol. 13
Résumé en anglais
Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated ...Lire la suite >
Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats. Copyright © 2022 Seal, Henry, Pajot, Holuka, Bailbé, Movassat, Darnaudéry and Turner.< Réduire
Mots clés en anglais
Diabetes
Obesity
Cytokines
Inflammation
Microarrays
Goto-Kakizaki rats
Project ANR
Diabète maternel et vulnérabilité neuropsychiatrique chez la descendance : rôle de la méthylation de l'ADN - ANR-17-CE37-0020
Unités de recherche