A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes
| dc.rights.license | open | en_US |
| hal.structure.identifier | Université du Luxembourg = University of Luxembourg = Universität Luxemburg [uni.lu] | |
| hal.structure.identifier | Luxembourg Institute of Health [LIH] | |
| dc.contributor.author | SEAL, Snehaa | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | HENRY, Mathilde | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | PAJOT, Clementine | |
| hal.structure.identifier | Université du Luxembourg = University of Luxembourg = Universität Luxemburg [uni.lu] | |
| hal.structure.identifier | Luxembourg Institute of Health [LIH] | |
| dc.contributor.author | HOLUKA, Cyrielle | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | BAILBE, Danielle | |
| hal.structure.identifier | Unité de Biologie Fonctionnelle et Adaptative [BFA (UMR_8251 / U1133)] | |
| dc.contributor.author | MOVASSAT, Jamileh | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DARNAUDERY, Muriel
IDREF: 124892264 | |
| hal.structure.identifier | Luxembourg Institute of Health [LIH] | |
| dc.contributor.author | TURNER, Jonathan | |
| dc.date.accessioned | 2023-01-16T15:00:16Z | |
| dc.date.available | 2023-01-16T15:00:16Z | |
| dc.date.issued | 2022-05-23 | |
| dc.identifier.issn | 1664-3224 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/171693 | |
| dc.description.abstractEn | Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats. Copyright © 2022 Seal, Henry, Pajot, Holuka, Bailbé, Movassat, Darnaudéry and Turner. | |
| dc.description.sponsorship | Diabète maternel et vulnérabilité neuropsychiatrique chez la descendance : rôle de la méthylation de l'ADN - ANR-17-CE37-0020 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Diabetes | |
| dc.subject.en | Obesity | |
| dc.subject.en | Cytokines | |
| dc.subject.en | Inflammation | |
| dc.subject.en | Microarrays | |
| dc.subject.en | Goto-Kakizaki rats | |
| dc.title.en | A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fimmu.2022.896179 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 35677049 | en_US |
| bordeaux.journal | Frontiers in immunology | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fonds National de la Recherche Luxembourg | en_US |
| bordeaux.identifier.funderID | Departement Alimentation Humaine, Institut National de la Recherche Agronomique | en_US |
| hal.identifier | hal-03941416 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-01-16T15:00:27Z | |
| hal.export | true | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20immunology&rft.date=2022-05-23&rft.volume=13&rft.eissn=1664-3224&rft.issn=1664-3224&rft.au=SEAL,%20Snehaa&HENRY,%20Mathilde&PAJOT,%20Clementine&HOLUKA,%20Cyrielle&BAILBE,%20Danielle&rft.genre=article |
