LE FAOUDER, Julie; ARNAUD, Bastien; LAVIGNE, Regis; LUCAS, Celine; COM, Emmanuelle; BOUVRET, Elodie; DINEL, Anne Laure; PINEAU, Charles

doi:10.3390/foods11111591

LE FAOUDER, Julie
Proteomics Core Facility [Protim]
Abyss Ingredients

ARNAUD, Bastien
Proteomics Core Facility [Protim]

LAVIGNE, Regis
Institut de recherche en santé, environnement et travail [Irset]
Proteomics Core Facility [Protim]

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Article de revue

Ce document a été publié dans

Foods. 2022-05-28, vol. 11, n° 11

Résumé en anglais

Over the past several decades, stress has dramatically increased in occidental societies. The use of natural resources, such as fish hydrolysates, may be an attractive strategy to improve stress management. Our previous study demonstrated the anxiolytic effects of fish hydrolysate supplementation in mice exposed to acute mild stress by limiting stress‐induced corticosterone release and modulating the expression of a number of stress‐responsive genes. Here, we explore hippocampal protein modulation induced by fish hydrolysate supplementation in mice submitted to acute mild stress, with the aim of better elucidating the underlying mechanisms. Hippocampi from the same cohort of Balb/c mice supplemented with fish hydrolysate (300 mg∙kg−1 body weight) or vehicle daily for seven days before being submitted or not to an acute mild stress protocol (four groups, n = 8/group) were subjected to label‐free quantitative proteomics analysis combined with gene ontology data mining. Our results show that fish hydrolysate supplementation prevented the observed stress‐induced dysregulation of proteins relative to mitochondrial pathways and the neuronal network. These findings suggest that fish hydrolysate represents an innovative strategy to prevent the adverse effects of stress and participate in stress management. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.< Réduire

Mots clés en anglais

Fish hydrolysate

Proteomics

Acute mild stress

Mouse

Hippocampus

Mitochondria

Neuronal network

URI

https://oskar-bordeaux.fr/handle/20.500.12278/171661

DOI

http://dx.doi.org/10.3390/foods11111591

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Fish Hydrolysate Supplementation Prevents Stress‐Induced Dysregulation of Hippocampal Proteins Relative to Mitochondrial Metabolism and the Neuronal Network in Mice

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Résumé en anglais

Mots clés en anglais

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