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Resveratrol and Some of Its Derivatives as Promising Prophylactic Treatments for Neonatal Hypoxia-Ischemia.
Language
EN
Article de revue
This item was published in
Nutrients. 2022-09-14, vol. 14, n° 18, p. 3793
English Abstract
Due to the rate of occurrence of neonatal hypoxia-ischemia, its neuronal sequelae, and the lack of effective therapies, the development of new neuroprotective strategies is required. Polyphenols (including resveratrol) are ...Read more >
Due to the rate of occurrence of neonatal hypoxia-ischemia, its neuronal sequelae, and the lack of effective therapies, the development of new neuroprotective strategies is required. Polyphenols (including resveratrol) are molecules whose anti-apoptotic, anti-inflammatory, and anti-oxidative properties could be effective against the damage induced by neonatal hypoxia-ischemia. In this review article, very recent data concerning the neuroprotective role of polyphenols and the mechanisms at play are detailed, including a boost in brain energy metabolism. The results obtained with innovative approaches, such as maternal supplementation at nutritional doses, suggest that polyphenols could be a promising prophylactic treatment for neonatal hypoxia-ischemia.Read less <
English Keywords
Animals
Animals
Newborn
Hypoxia-Ischemia
Brain
Ischemia
Neuroprotective Agents
Polyphenols
Resveratrol
ANR Project
Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057
Exploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003
Exploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003