ROUMES, Helene; GOUDENECHE, Pierre; PELLERIN, Luc; BOUZIER-SORE, Anne-Karine

doi:10.3390/nu14183793

ROUMES, Helene
Centre de résonance magnétique des systèmes biologiques [CRMSB]

GOUDENECHE, Pierre
Centre de résonance magnétique des systèmes biologiques [CRMSB]

PELLERIN, Luc

Langue

Article de revue

Ce document a été publié dans

Nutrients. 2022-09-14, vol. 14, n° 18, p. 3793

Résumé en anglais

Due to the rate of occurrence of neonatal hypoxia-ischemia, its neuronal sequelae, and the lack of effective therapies, the development of new neuroprotective strategies is required. Polyphenols (including resveratrol) are molecules whose anti-apoptotic, anti-inflammatory, and anti-oxidative properties could be effective against the damage induced by neonatal hypoxia-ischemia. In this review article, very recent data concerning the neuroprotective role of polyphenols and the mechanisms at play are detailed, including a boost in brain energy metabolism. The results obtained with innovative approaches, such as maternal supplementation at nutritional doses, suggest that polyphenols could be a promising prophylactic treatment for neonatal hypoxia-ischemia.< Réduire

Mots clés en anglais

Animals

Newborn

Hypoxia-Ischemia

Brain

Ischemia

Neuroprotective Agents

Polyphenols

Resveratrol

URI

https://oskar-bordeaux.fr/handle/20.500.12278/170343

DOI

http://dx.doi.org/10.3390/nu14183793

Project ANR

Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057
Exploration in vivo du couplage métabolique entre neurones et astrocytes lors de l'activation cérébrale: étude par spectroscopie de RMN - ANR-15-CE37-0012
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003

Unités de recherche

Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536

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Resveratrol and Some of Its Derivatives as Promising Prophylactic Treatments for Neonatal Hypoxia-Ischemia.