JORES, Joerg; SCHIECK, Elise; LILJANDER, Anne; SACCHINI, Flavio; POSTHAUS, Horst; LARTIGUE, Carole; BLANCHARD, Alain; LABROUSSAA, Fabien; VASHEE, Sanjay

doi:10.1093/infdis/jiy713

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Licence d’utilisation du document

JORES, Joerg
Universität Bern = University of Bern = Université de Berne [UNIBE]
International Livestock Research Institute [CGIAR, Nairobi] [ILRI]

SCHIECK, Elise
International Livestock Research Institute [CGIAR, Nairobi] [ILRI]

LILJANDER, Anne
International Livestock Research Institute [CGIAR, Nairobi] [ILRI]

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Article de revue

Ce document a été publié dans

Journal of Infectious Diseases. 2019, vol. 219, n° 10, p. 1559-1563

Oxford University Press

Résumé en anglais

Capsular polysaccharides have been confirmed to be an important virulence trait in many different Gram-positive and Gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In this study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. capri or an engineered mutant lacking the capsular polysaccharide, galactofuranose. Goats infected with the mutant strain showed only transient fever. In contrast, five out of eight goats infected with the parental strain reached endpoint criteria after infection. This work confirms that galactofuranose is a virulence factor in Mycoplasma mycoides.< Réduire

Mots clés

M. mycoides subsp. capri

galactofuranose

vaccine

Mots clés en anglais

Mycoplasma mycoides

carbohydrate

glycan

virulence factor

CPS