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In vivo role of capsular polysaccharide in <em>Mycoplasma mycoides</em>

hal.structure.identifierUniversität Bern / University of Bern [UNIBE]
hal.structure.identifierInternational Livestock Research Institute [CGIAR, Nairobi] [ILRI]
dc.contributor.authorJORES, Joerg
hal.structure.identifierInternational Livestock Research Institute [CGIAR, Nairobi] [ILRI]
dc.contributor.authorSCHIECK, Elise
hal.structure.identifierInternational Livestock Research Institute [CGIAR, Nairobi] [ILRI]
dc.contributor.authorLILJANDER, Anne
hal.structure.identifierUniversität Bern / University of Bern [UNIBE]
hal.structure.identifierInternational Livestock Research Institute [CGIAR, Nairobi] [ILRI]
dc.contributor.authorSACCHINI, Flavio
hal.structure.identifierUniversität Bern / University of Bern [UNIBE]
dc.contributor.authorPOSTHAUS, Horst
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorLARTIGUE, Carole
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBLANCHARD, Alain
hal.structure.identifierUniversität Bern / University of Bern [UNIBE]
dc.contributor.authorLABROUSSAA, Fabien
hal.structure.identifierJ. Craig Venter Institute [La Jolla, USA] [JCVI]
dc.contributor.authorVASHEE, Sanjay
dc.date.issued2019
dc.identifier.issn0022-1899
dc.description.abstractEnCapsular polysaccharides have been confirmed to be an important virulence trait in many different Gram-positive and Gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In this study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. capri or an engineered mutant lacking the capsular polysaccharide, galactofuranose. Goats infected with the mutant strain showed only transient fever. In contrast, five out of eight goats infected with the parental strain reached endpoint criteria after infection. This work confirms that galactofuranose is a virulence factor in Mycoplasma mycoides.
dc.language.isoen
dc.publisherOxford University Press
dc.subjectM. mycoides subsp. capri
dc.subjectgalactofuranose
dc.subjectvaccine
dc.subject.enMycoplasma mycoides
dc.subject.encarbohydrate
dc.subject.englycan
dc.subject.envirulence factor
dc.subject.enCPS
dc.title.enIn vivo role of capsular polysaccharide in <em>Mycoplasma mycoides</em>
dc.typeArticle de revue
dc.identifier.doi10.1093/infdis/jiy713
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Médecine vétérinaire et santé animal
dc.subject.halSciences du Vivant [q-bio]/Biologie animale
bordeaux.journalJournal of Infectious Diseases
bordeaux.page1559-1563
bordeaux.volume219
bordeaux.issue10
bordeaux.peerReviewedoui
hal.identifierhal-02629117
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02629117v1
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