Conducting and permeable states of cell membrane submitted to high voltage pulses: Mathematical and numerical studies validated by the experiments
Language
en
Article de revue
This item was published in
Journal of Theoretical Biology. 2014-11-07, vol. 360, p. 83-94
Elsevier
English Abstract
The aim of this paper is to present a new model of in vitro cell electropermeabilization, which describes separately the conducting state and the permeable state of the membrane submitted to high voltage pulses. We first ...Read more >
The aim of this paper is to present a new model of in vitro cell electropermeabilization, which describes separately the conducting state and the permeable state of the membrane submitted to high voltage pulses. We first derive the model based on the experimental observations and we present the numerical methods to solve the non-linear partial differential equations. We then present numerical simulations that corroborate qualitatively the experimental data dealing with the uptake of propidium iodide (PI) after millipulses. This tends to justify the validity of our modeling. Forthcoming work will be to calibrate the parameters of the model for quantitative description of the uptake.Read less <
Italian Keywords
Cell modeling
Non-linear partial differential equations
Finite differences on cartesian grid
Surface diffusion discretization
ANR Project
Modélisation multi-échelle de l'électroporation validée par les expériences - ANR-11-BS01-0006
Origin
Hal imported