LEGUEBE, Michael; SILVE, Aude; MIR, Lluis M; POIGNARD, Clair

doi:10.1016/j.jtbi.2014.06.027

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Licencia de uso del documento

LEGUEBE, Michael
Institut de Mathématiques de Bordeaux [IMB]
Modélisation, contrôle et calcul [MC2]

SILVE, Aude
Institute for Pulsed Power and Microwave Technology [Eggenstein-Leopoldshafen]

MIR, Lluis M
Vectorologie et transfert de gènes [VTG / UMR8121]

Idioma

Article de revue

Este ítem está publicado en

Journal of Theoretical Biology. 2014-11-07, vol. 360, p. 83-94

Elsevier

Resumen en inglés

The aim of this paper is to present a new model of in vitro cell electropermeabilization, which describes separately the conducting state and the permeable state of the membrane submitted to high voltage pulses. We first derive the model based on the experimental observations and we present the numerical methods to solve the non-linear partial differential equations. We then present numerical simulations that corroborate qualitatively the experimental data dealing with the uptake of propidium iodide (PI) after millipulses. This tends to justify the validity of our modeling. Forthcoming work will be to calibrate the parameters of the model for quantitative description of the uptake.< Leer menos

Palabras clave en italiano

Cell modeling

Non-linear partial differential equations

Finite differences on cartesian grid

Surface diffusion discretization

DOI

http://dx.doi.org/10.1016/j.jtbi.2014.06.027

Proyecto ANR

Modélisation multi-échelle de l'électroporation validée par les expériences - ANR-11-BS01-0006

Orígen

Importado de Hal

Centros de investigación

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251