Pharmaceuticals perspectives of high pressure : a soft tool for sterilization of fragile drugs
RIGALDIE, Yohan
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]
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Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]
RIGALDIE, Yohan
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]
< Réduire
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]
Langue
en
Article de revue
Ce document a été publié dans
Defect and Diffusion Forum. 2002, vol. 208-209, p. 55-58
Trans Tech Publications
Résumé en anglais
In this study, we showed the safety of HHP (High Hydrostatic Pressure) treatment on several fragile biomolecules (molecular weight from 1200 up to 150 000 g/mol : two peptides, insulin, antibodies). A HHP treatment (10 min ...Lire la suite >
In this study, we showed the safety of HHP (High Hydrostatic Pressure) treatment on several fragile biomolecules (molecular weight from 1200 up to 150 000 g/mol : two peptides, insulin, antibodies). A HHP treatment (10 min at 400 MPa) inactivates totally pure suspensions of P. aeruginosa and C. albicans. HHP at low temperature induces a stronger inactivation than at room temperature. S. aureus needs a longer HHP duration treatment or a multi-step treatment to be totally inactivated. But same tests applied to B. subtilis did not lead to a total inactivation; furtherprocesses are in progress in order to cause spores of B. subtilis to germinate< Réduire
Mots clés en anglais
High pressure
Drugs
Sterilization
Origine
Importé de halUnités de recherche