RIGALDIE, Yohan; LEMAGNEN, Gilles; LARGETEAU, Alain; LARROUTURE, Denis; ABBA, M.; HALLER, R.; GRISLAIN, Luc; DEMAZEAU, Gérard

doi:10.4028/www.scientific.net/DDF.208-209.55

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RIGALDIE, Yohan
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]

LEMAGNEN, Gilles
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]

LARGETEAU, Alain
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]

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Defect and Diffusion Forum. 2002, vol. 208-209, p. 55-58

Trans Tech Publications

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In this study, we showed the safety of HHP (High Hydrostatic Pressure) treatment on several fragile biomolecules (molecular weight from 1200 up to 150 000 g/mol : two peptides, insulin, antibodies). A HHP treatment (10 min at 400 MPa) inactivates totally pure suspensions of P. aeruginosa and C. albicans. HHP at low temperature induces a stronger inactivation than at room temperature. S. aureus needs a longer HHP duration treatment or a multi-step treatment to be totally inactivated. But same tests applied to B. subtilis did not lead to a total inactivation; furtherprocesses are in progress in order to cause spores of B. subtilis to germinate< Leer menos

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High pressure

Drugs

Sterilization

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Pharmaceuticals perspectives of high pressure : a soft tool for sterilization of fragile drugs

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