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Pharmaceuticals perspectives of high pressure : a soft tool for sterilization of fragile drugs

hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
hal.structure.identifierEllipse Pharmaceutical
hal.structure.identifierLaboratoire de Technologie Pharmaceutique Industrielle [LTIP]
dc.contributor.authorRIGALDIE, Yohan
hal.structure.identifierLaboratoire de Technologie Pharmaceutique Industrielle [LTIP]
dc.contributor.authorLEMAGNEN, Gilles
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLARGETEAU, Alain
hal.structure.identifierLaboratoire de Technologie Pharmaceutique Industrielle [LTIP]
dc.contributor.authorLARROUTURE, Denis
hal.structure.identifierEllipse Pharmaceutical
hal.structure.identifierLaboratoire de Technologie Pharmaceutique Industrielle [LTIP]
dc.contributor.authorABBA, M.
hal.structure.identifierEllipse Pharmaceutical
dc.contributor.authorHALLER, R.
hal.structure.identifierLaboratoire de Technologie Pharmaceutique Industrielle [LTIP]
dc.contributor.authorGRISLAIN, Luc
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDEMAZEAU, Gérard
dc.date.issued2002
dc.identifier.issn1012-0386
dc.description.abstractEnIn this study, we showed the safety of HHP (High Hydrostatic Pressure) treatment on several fragile biomolecules (molecular weight from 1200 up to 150 000 g/mol : two peptides, insulin, antibodies). A HHP treatment (10 min at 400 MPa) inactivates totally pure suspensions of P. aeruginosa and C. albicans. HHP at low temperature induces a stronger inactivation than at room temperature. S. aureus needs a longer HHP duration treatment or a multi-step treatment to be totally inactivated. But same tests applied to B. subtilis did not lead to a total inactivation; furtherprocesses are in progress in order to cause spores of B. subtilis to germinate
dc.language.isoen
dc.publisherTrans Tech Publications
dc.subject.enHigh pressure
dc.subject.enDrugs
dc.subject.enSterilization
dc.title.enPharmaceuticals perspectives of high pressure : a soft tool for sterilization of fragile drugs
dc.typeArticle de revue
dc.identifier.doi10.4028/www.scientific.net/DDF.208-209.55
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques
dc.subject.halSciences de l'ingénieur [physics]/Génie des procédés
bordeaux.journalDefect and Diffusion Forum
bordeaux.page55-58
bordeaux.volume208-209
bordeaux.peerReviewedoui
hal.identifierhal-00715310
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00715310v1
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