Pharmaceuticals perspectives of high pressure : a soft tool for sterilization of fragile drugs
RIGALDIE, Yohan
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]
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Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]
RIGALDIE, Yohan
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]
< Reduce
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Ellipse Pharmaceutical
Laboratoire de Technologie Pharmaceutique Industrielle [LTIP]
Language
en
Article de revue
This item was published in
Defect and Diffusion Forum. 2002, vol. 208-209, p. 55-58
Trans Tech Publications
English Abstract
In this study, we showed the safety of HHP (High Hydrostatic Pressure) treatment on several fragile biomolecules (molecular weight from 1200 up to 150 000 g/mol : two peptides, insulin, antibodies). A HHP treatment (10 min ...Read more >
In this study, we showed the safety of HHP (High Hydrostatic Pressure) treatment on several fragile biomolecules (molecular weight from 1200 up to 150 000 g/mol : two peptides, insulin, antibodies). A HHP treatment (10 min at 400 MPa) inactivates totally pure suspensions of P. aeruginosa and C. albicans. HHP at low temperature induces a stronger inactivation than at room temperature. S. aureus needs a longer HHP duration treatment or a multi-step treatment to be totally inactivated. But same tests applied to B. subtilis did not lead to a total inactivation; furtherprocesses are in progress in order to cause spores of B. subtilis to germinateRead less <
English Keywords
High pressure
Drugs
Sterilization
Origin
Hal imported