MEYNARD, Joane; AMADO-BECKER, F; TCHORELOFF, Pierre; MAZEL, Vincent

doi:10.1016/j.ijpharm.2022.121818

Institut de Mécanique et d'Ingénierie [I2M]

AMADO-BECKER, F

TCHORELOFF, Pierre

Institut de Mécanique et d'Ingénierie [I2M]

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Article de revue

Ce document a été publié dans

International Journal of Pharmaceutics. 2022-05-12, vol. 621, p. 121818

Résumé en anglais

Capping is a common defect that can occur during the manufacturing of pharmaceutical tablets. Several studies showed that decreasing the unloading speed of the manufacturing cycle plays a role in the occurrence of such defects. Following this idea, we study in this work the influence of the unloading step on capping using a compaction simulator. Measuring the die wall pressure made it possible to detect precisely that tablets capped just after the unloading (some milliseconds only). To evaluate the impact of the unloading speed on capping, we developed a two-step unloading phase controlled by three manufacturing parameters. It was possible to mitigate capping by decreasing the speed at which the contact between the punches and the tablet was lost. Capping seemed due to dynamical effects related to the release of the axial pressure. The modification of the unloading step to mitigate capping led to significant changes in tablet density but no clear trends were found for the residual die-wall pressure and tablet strength. This work made it possible to improve the understanding of capping. Moreover, the two-step unloading cycle gave a new idea for possible modifications that could be done on rotary presses in order to mitigate capping.< Réduire

Mots clés en anglais

Biomechanical Phenomena

Powders

Pressure

Tablets

Tensile Strength

URI

https://oskar-bordeaux.fr/handle/20.500.12278/140601

DOI

http://dx.doi.org/10.1016/j.ijpharm.2022.121818

Unités de recherche

Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295

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Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets

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Résumé en anglais

Mots clés en anglais

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