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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorMEYNARD, Joane
dc.contributor.authorAMADO-BECKER, F
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorTCHORELOFF, Pierre
IDREF: 069233624
hal.structure.identifierInstitut de Mécanique et d'Ingénierie [I2M]
dc.contributor.authorMAZEL, Vincent
IDREF: 113057954
dc.date.accessioned2022-08-29T09:45:34Z
dc.date.available2022-08-29T09:45:34Z
dc.date.issued2022-05-12
dc.identifier.issn1873-3476en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140601
dc.description.abstractEnCapping is a common defect that can occur during the manufacturing of pharmaceutical tablets. Several studies showed that decreasing the unloading speed of the manufacturing cycle plays a role in the occurrence of such defects. Following this idea, we study in this work the influence of the unloading step on capping using a compaction simulator. Measuring the die wall pressure made it possible to detect precisely that tablets capped just after the unloading (some milliseconds only). To evaluate the impact of the unloading speed on capping, we developed a two-step unloading phase controlled by three manufacturing parameters. It was possible to mitigate capping by decreasing the speed at which the contact between the punches and the tablet was lost. Capping seemed due to dynamical effects related to the release of the axial pressure. The modification of the unloading step to mitigate capping led to significant changes in tablet density but no clear trends were found for the residual die-wall pressure and tablet strength. This work made it possible to improve the understanding of capping. Moreover, the two-step unloading cycle gave a new idea for possible modifications that could be done on rotary presses in order to mitigate capping.
dc.language.isoENen_US
dc.subject.enBiomechanical Phenomena
dc.subject.enPowders
dc.subject.enPressure
dc.subject.enTablets
dc.subject.enTensile Strength
dc.title.enImpact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets
dc.title.alternativeInt J Pharmen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ijpharm.2022.121818en_US
dc.subject.halSciences de l'ingénieur [physics]/Matériaux
dc.identifier.pubmed35568243en_US
bordeaux.journalInternational Journal of Pharmaceuticsen_US
bordeaux.page121818en_US
bordeaux.volume621en_US
bordeaux.hal.laboratoriesInstitut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionArts et Métiersen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03776431
hal.version1
hal.date.transferred2022-09-13T14:49:56Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Pharmaceutics&rft.date=2022-05-12&rft.volume=621&rft.spage=121818&rft.epage=121818&rft.eissn=1873-3476&rft.issn=1873-3476&rft.au=MEYNARD,%20Joane&AMADO-BECKER,%20F&TCHORELOFF,%20Pierre&MAZEL,%20Vincent&rft.genre=article


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