GALLERANI, E.; PROIETTO, D.; DALLAN, B.; CAMPAGNARO, M.; PACIFICO, S.; ALBANESE, V.; MARZOLA, E.; MARCONI, P.; CAPUTO, A.; APPAY, Victor; GAVIOLI, R.; NICOLI, F.

doi:10.3389/fimmu.2021.693054

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Frontiers in Immunology. 2021, vol. 12

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Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8+ T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8+ T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8+ T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8+ T-cell responses.< Réduire

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CD8+ T cells

Cellular immunity

Epitopes

Immune aging

Naive T cells

Primary responses

SARS-CoV-2

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Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects

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