Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects
| dc.rights.license | open | en_US |
| dc.contributor.author | GALLERANI, E. | |
| dc.contributor.author | PROIETTO, D. | |
| dc.contributor.author | DALLAN, B. | |
| dc.contributor.author | CAMPAGNARO, M. | |
| dc.contributor.author | PACIFICO, S. | |
| dc.contributor.author | ALBANESE, V. | |
| dc.contributor.author | MARZOLA, E. | |
| dc.contributor.author | MARCONI, P. | |
| dc.contributor.author | CAPUTO, A. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | APPAY, Victor | |
| dc.contributor.author | GAVIOLI, R. | |
| dc.contributor.author | NICOLI, F. | |
| dc.date.accessioned | 2022-05-02T15:53:20Z | |
| dc.date.available | 2022-05-02T15:53:20Z | |
| dc.date.issued | 2021 | |
| dc.identifier.issn | 1664-3224 | en_US |
| dc.identifier.other | https://www.frontiersin.org/articles/10.3389/fimmu.2021.693054/ full#supplementary-material | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139959 | |
| dc.description.abstractEn | Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8+ T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8+ T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8+ T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8+ T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8+ T-cell responses. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | CD8+ T cells | |
| dc.subject.en | Cellular immunity | |
| dc.subject.en | Epitopes | |
| dc.subject.en | Immune aging | |
| dc.subject.en | Naive T cells | |
| dc.subject.en | Primary responses | |
| dc.subject.en | SARS-CoV-2 | |
| dc.title.en | Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fimmu.2021.693054 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 34326844 | en_US |
| bordeaux.journal | Frontiers in Immunology | en_US |
| bordeaux.volume | 12 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03657268 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-05-02T15:53:21Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Immunology&rft.date=2021&rft.volume=12&rft.eissn=1664-3224&rft.issn=1664-3224&rft.au=GALLERANI,%20E.&PROIETTO,%20D.&DALLAN,%20B.&CAMPAGNARO,%20M.&PACIFICO,%20S.&rft.genre=article |
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